Hydrogenation of substituted 5-acyl-1,3-dioxanes in the presence of a Pd/C catalyst leads to the formation of substituted 1,3-dioxane alcohols as the only reaction products. The effect of a number of factors (temperature, rate of hydrogen and substrate supply) on the conversion of the ketone and the selectivity of the formation of alcohol was investigated.
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This study was carried out with the financial support of the Ufa State Petroleum Technical University (competition of leadership projects, nomination “Scientific Research Fund”). Structural researches were carried out at the Regional Center for collective use “Agidel” at the Ufa Federal Research Center of the Russian Academy of Sciences as part of a state assignment (project AAAA-A19-119022290004-8).
No conflict of interest was declared by the authors.
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Borisova, Y.G., Musin, A.I., Yakupov, N.V. et al. Pd/C-Catalyzed Hydrogenation of Substituted 5-Acyl-1,3-dioxanes. Russ J Gen Chem 91, 1619–1622 (2021). https://doi.org/10.1134/S1070363221090036
- Pd/C catalyst