Skip to main content
SpringerLink
Log in

Palladium(II) Complexes with Catecholamines: Synthesis and In Vitro Cytotoxic Activity

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

The reactions of palladium(II) chloride with catecholamines (hydrochlorides of 3-methoxytyramine, normetanephrine, norepinephrine, and dopamine) and pyridine-2-carbaldehyde have afforded four new palladium complexes of different types (pyridine-imine, oxazolidine-imine, and cation-anionic ones). Structure of the obtained complexes have been confirmed by means of NMR spectroscopy and X-ray diffraction analysis. Cytotoxic activity of the complexes with respect to PC3 (prostate cancer cells) and HEK-293 (human epithelial kidney cells) cell lines has been estimated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme
Scheme
Fig. 1.
Scheme
Scheme

Similar content being viewed by others

REFERENCES

  1. Denisov, M.S. and Glushkov, V.A., Vestn. Permsk. Univ., Ser. Khim., 2018, vol. 4, no. 4, p. 388. https://doi.org/10.17072/2223-1838-2018-4-388-411

    Article  Google Scholar 

  2. Serratrice, M., Maiore, L., Zucca, A., Stoccoro, S., Landini, I., Mini, E., Massai, L., Ferraro, G., Merlino, A., Messori, L., and Cinellu, M.A., Dalton Trans., 2016, vol. 45, p. 579. https://doi.org/10.1039/C5DT02714D

    Article  PubMed  CAS  Google Scholar 

  3. Mitra, I., Mukherjee, S., Reddy, B.V.P., Misini, B., Das, P., Dasgupta, S., Linert, W., and Moi, S.Ch., New J. Chem., 2018, vol. 42, p. 2574. https://doi.org/10.1039/C7NJ05173E

    Article  CAS  Google Scholar 

  4. Egorova, K.S., Galushko, A.S., and Ananikov, V.P., Angew. Chem. Int. Ed., 2020, vol. 59, p. 22296. https://doi.org/10.1002/anie.202003082

    Article  CAS  Google Scholar 

  5. Valentini, A., Conforti, F., Crispini, A., Martino, A.D., Condello, R., Stellitano, C., Rotilio, G., Ghedini, M., Federici, G., Bernardini, S., and Pucci, D., J. Med. Chem., 2009, vol. 52, no. 2, p. 484. https://doi.org/10.1021/jm801276a

    Article  PubMed  CAS  Google Scholar 

  6. Büyükekşi, S.I., Erkısa, M., Şengül, A., Ulukaya, E., and Oral, A.Y., Appl. Organometal. Chem., 2018, vol. 32, no. 8, p. e4406. https://doi.org/10.1002/aoc.4406

  7. Ulukaya, E., Ari, F., Dimas, K.,·Sarimahmut, M., Guney, E., Sakellaridis, N.,·and Yilmaz, V.T., J. Cancer Res. Clin. Oncol., 2011, vol. 137, p. 1425. https://doi.org/10.1007/s00432-011-1021-1

    Article  PubMed  CAS  Google Scholar 

  8. Denisov, M.S. and Glushkov, V.A., Russ. Chem. Bull., 2020, vol. 69, no. 10, p. 2013. https://doi.org/10.1007/s11172-020-2993-2

    Article  CAS  Google Scholar 

  9. Gonçalves, B.M.F., Salvador, J.A.R., Marín, S., and Cascante, M., Eur. J. Med. Chem., 2016, vol. 114, p. 101. https://doi.org/10.1016/j.ejmech.2016.02.057

    Article  PubMed  CAS  Google Scholar 

  10. Haribabu, J., Srividya, S., Mahendiran, D., Gayathri, D., Venkatramu, V., Bhuvanesh, N., and Karvembu, R., Inorg. Chem., 2020, vol. 59, no. 23, p. 17109. https://doi.org/10.1021/acs.inorgchem.0c02373

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Gichumbi, J.M., Friedrich, H.B., Omondi, B., Singh, M., Naidoo, K., and Chenia, H.Y., J. Coord. Chem., 2016, vol. 69, no. 23, p. 3531. https://doi.org/10.1080/00958972.2016.1243238

    Article  CAS  Google Scholar 

  12. Reddy, E.R., Trivedi, R., Sarma, A.V.S., Sridhar, B., Anantaraju, H.Sh., Sriram, D., Yogeeswarid, P., and Nagesh, N., Dalton Trans., 2015, vol. 44, p. 17600. https://doi.org/10.1039/C5DT03266K

    Article  PubMed  CAS  Google Scholar 

  13. Denisov, M.S., Gagarskih, O.N., and Utushkina, T.A., Vestn. Permsk. Univ., Ser. Khim., 2021, vol. 11, no. 1, p. 30. https://doi.org/10.17072/2223-1838-2021-1-30-58

    Article  Google Scholar 

  14. Striegler, S. and Dittel, M., Inorg. Chem., 2005, vol. 44, no. 8, p. 2728. https://doi.org/10.1021/ic048724p

    Article  PubMed  CAS  Google Scholar 

  15. Molaeea, H., Moghadama, M., Mirkhania, V. Tangestaninejada, Sh., Mohammadpoor-Baltorka, I., Kajania, A.A., and Kia, R., Polyhedron., 2019, vol. 160, no. 1, p. 130. https://doi.org/10.1016/j.poly.2018.11.037

    Article  CAS  Google Scholar 

  16. Motswainyana, W.M., Onani, M.O., Madiehe, A.M., Saibu, M., Jacobs, J., and van Meervelt, L., Inorg. Chimica Acta, 2013, vol. 400, no. 1, p. 197. https://doi.org/10.1016/j.ica.2013.02.029

    Article  CAS  Google Scholar 

  17. Shaidarova, L.G., Chelnokova, I.A., Leksina, Y.A., Gedmina, A.V., and Budnikov, H.C., J. Anal. Chem., 2020, vol. 75, no. 8, p. 1059. https://doi.org/10.1134/S1061934820080134

    Article  CAS  Google Scholar 

  18. Ossola, B., Schendzielorz, N., Chen, Sh.-H., Bird, G.S., Tuominen, R.K., Männistö, P.T., and Hong, J.-Sh., Neuropharmacology, 2011, vol. 61, no. 4, p. 574. https://doi.org/10.1016/j.neuropharm.2011.04.030

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Zalevskaya, O.A., Gur’eva, Ya.A., and Kutchin, A.V., Russ. Chem. Rev., 2019, vol. 88, no. 10, p. 979. https://doi.org/10.1070/RCR4880

    Article  CAS  Google Scholar 

  20. Denisov, M.S., Dmitriev, M.V., Eroshenko, D.V., Slepukhin, P.A., Shavkunov, S.P., and Glushkov, V.A., Russ. J. Inorg. Chem., 2019, vol. 64, no. 1, p. 56. https://doi.org/10.1134/S0036023619010054

    Article  CAS  Google Scholar 

  21. CrysAlisPro, Agilent Technologies, Version 1.171.37.33 (release 27-03-2014 CrysAlis171 .NET).

  22. Sheldrick, G.M., Acta Crystallogr. (A), 2015, vol. 71, p. 3. https://doi.org/10.1107/S2053273314026370

    Article  CAS  Google Scholar 

  23. Sheldrick, G.M., Acta Crystallogr. (C), 2015, vol. 71, p. 3. https://doi.org/10.1107/S2053229614024218

    Article  CAS  Google Scholar 

  24. Dolomanov, O.V., Bourhis, L.J., Gildea, R.J., Howard, J.A.K., and Puschmann, H., J. Appl. Cryst., 2009, vol. 42, p. 339. https://doi.org/10.1107/S0021889808042726

    Article  CAS  Google Scholar 

  25. Mercury 3.3 (Build RC5). Cambridge: Cambridge Crystallographic Data Centre, 2013. http://www.ccdc.cam.ac.uk/mercury/

Download references

ACKNOWLEDGMENTS

The work was carried out using the equipment of The Core Facilities Center “Research of materials and matter” at the Perm Federal Research Center, Ural Branch, RAS. Authors are grateful to O.A. Mayorova (Institute of Technical Chemistry of Ural Branch, Russian Academy of Sciences) for recording the NMR spectra, D.K. Trukhinov and D.M. Kiselkov (Institute of Technical Chemistry of Ural Branch, Russian Academy of Sciences) for recording the IR spectra, M.V. Dmitriev (Perm State National Research University) for the X-ray diffraction analysis, T.E. Oschepkova (Institute of Technical Chemistry of Ural Branch, Russian Academy of Sciences) for performing the thermogravimetric analysis, S.P. Shavkunov (Perm State National Research University) for performing the conductometry measurements, and Yu.А. Beloglazova and A.O. Voronina (Institute of Technical Chemistry of Ural Branch, Russian Academy of Sciences) for the assistance in performing the MTT test.

Funding

The reported study was funded by Russian Foundation for Basic Research and Ministry of Education and Science of Perm District according to the research project no. 19-43-590003.

Author information

Authors and Affiliations

  1. Institute of Technical Chemistry of Ural Branch, Russian Academy of Sciences, 614013, Perm, Russia

    M. S. Denisov & O. N. Gagarskikh

Authors
  1. M. S. Denisov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. N. Gagarskikh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. S. Denisov.

Ethics declarations

No conflict of interest was declared by the authors.

Additional information

Translated from Zhurnal Obshchei Khimii, 2021, Vol. 91, No. 7, pp. 1092–1099 https://doi.org/10.31857/S0044460X21070131.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Denisov, M.S., Gagarskikh, O.N. Palladium(II) Complexes with Catecholamines: Synthesis and In Vitro Cytotoxic Activity. Russ J Gen Chem 91, 1354–1360 (2021). https://doi.org/10.1134/S1070363221070136

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363221070136

Keywords:

Search

Navigation