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Synthesis of Triazolylisatins Glycoconjugates and Some Ammonium Hydrazones on Their Basis

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Abstract

The click reaction of propargylisatins with some azido-sugars was used to synthesize new isatin derivatives, in which the carbohydrate residue is linked to the 2,3-dioxindole scaffold via the 1,2,3-triazole ring. A number of water-soluble acylhydrazones with various structure of cationic fragment were obtained on their basis. It was shown that the newly obtained compounds do not exhibit hemotoxic action and have a significant antiaggregatory and anticoagulant activity at the level of reference drugs such as acetylsalicylic acid and pentoxifylline.

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ACKNOWLEDGMENTS

The authors are grateful to the Collective Spectro-Analytical Center for Physicochemical Studies of the Structure, Properties and Composition of Substances and Materials of the Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences” for technical support. This work was carried out within the framework of a cooperation agreement between the Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences” and the Bashkir State Medical University of the Ministry of Health of the Russian Federation.

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Authors and Affiliations

  1. A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of Russian Academy of Sciences”, 420088, Kazan, Russia

    A. V. Bogdanov, O. V. Andreeva, M. G. Belenok, A. D. Voloshina & V. F. Mironov

  2. Bashkir State Medical University, 450000, Ufa, Russia

    K. I. Enikeeva & A. V. Samorodov

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  1. A. V. Bogdanov
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  2. O. V. Andreeva
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  3. M. G. Belenok
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  4. A. D. Voloshina
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  5. K. I. Enikeeva
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  6. A. V. Samorodov
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  7. V. F. Mironov
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Correspondence to A. V. Bogdanov.

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V.F. Mironov is a member of the Editorial Board of the Russian Journal of General Chemistry. The other authors declare no conflict of interest.

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Translated from Zhurnal Obshchei Khimii, 2021, Vol. 91, No. 7, pp. 1010–1020 https://doi.org/10.31857/S0044460X21070040.

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Bogdanov, A.V., Andreeva, O.V., Belenok, M.G. et al. Synthesis of Triazolylisatins Glycoconjugates and Some Ammonium Hydrazones on Their Basis. Russ J Gen Chem 91, 1282–1291 (2021). https://doi.org/10.1134/S1070363221070045

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