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Synthesis and Pharmacological Activity of Some Novel Macrocyclic Pentapeptidopyridine and 3,5-Bis(tripeptidohydrazone)pyridine Schiff Bases

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Abstract

New Schiff bases containing macrocyclic 3,5-pyridine pentapeptide, linear 3,5-bis(tripeptido)pyridine methyl ester and hydrazide moieties have been synthesized from a dipeptide ester. The synthesized compounds have been tested as analgesic and anticonvulsant agents using Voltarene® and Carbamazepine® as reference drugs.

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Funding

The authors are grateful to the Deanship of Scientific Research, King Saud University for funding this work through Research Group Project “RGP-1435-047.”

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Authors and Affiliations

  1. Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia

    A. E. Amr

  2. Applied Organic Chemistry Department, National Research Centre, Dokki, 12622, Giza, Egypt

    A. E. Amr

  3. Zoology Department, Bioproducts Research Chair, Faculty of Science, King Saud University, 11451, Riyadh, Saudi Arabia

    E. A. Elsayed & A. I. Al-Sayady

  4. Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, 12622, Cairo, Egypt

    E. A. Elsayed

  5. Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O. Box 2457, 11451, Riyadh, Saudi Arabia

    E. Ezzeldin

Authors
  1. A. E. Amr
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  2. E. A. Elsayed
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  3. E. Ezzeldin
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  4. A. I. Al-Sayady
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Correspondence to A. E. Amr.

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Amr, A.E., Elsayed, E.A., Ezzeldin, E. et al. Synthesis and Pharmacological Activity of Some Novel Macrocyclic Pentapeptidopyridine and 3,5-Bis(tripeptidohydrazone)pyridine Schiff Bases. Russ J Gen Chem 91, 926–931 (2021). https://doi.org/10.1134/S1070363221050248

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