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Synthesis and Antimicrobial Activity of New 4-Methyl-2-(3-pyridyl)thiazolyl Chalcones and Pyrazolines

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An Erratum to this article was published on 01 April 2021

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Abstract

In an attempt to develop active antimicrobial agents, a set of new thiazolyl chalcones has been synthesized by the Claisen–Schmidt reaction of 5-acetyl-4-methyl-2-(3-pyridyl)thiazole with various heterocyclic aldehydes in alkali media. Reaction of chalcones with hydrazine hydrate has resulted in pyrazolines that have been assessed for in vitro antimicrobial activity against ten bacterial and five fungal human pathogenic strains using the disk diffusion assay. The synthesized pyrazolines demonstrate antimicrobial activity higher than that of synthesized chalcones. 2-Thienylchalcone has been determined as the most active against P. aeruginosa. Three pyrazolines are characterized by distinctive activity towards Gram-negative bacteria S. flexneri and P. aeruginosa. Two pyrazolines demonstrate equipotent antifungal activity with amphotricin B against A. clavatus.

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Funding

The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through a research group project under grant no. RGP.1/32/42. The authors would like to express their gratitude to King Khalid University, Abha, Saudi Arabia for providing administrative and technical support.

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Authors and Affiliations

  1. Chemistry Department, College of Science, King Khalid University, 9004, Abha, Saudi Arabia

    S. Bondock

  2. Chemistry Department, Faculty of Science, Mansoura University, 35516, Mansoura, Egypt

    S. Bondock

  3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, 11795, Cairo, Egypt

    T. Nasr

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  1. S. Bondock
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  2. T. Nasr
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Correspondence to S. Bondock.

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Bondock, S., Nasr, T. Synthesis and Antimicrobial Activity of New 4-Methyl-2-(3-pyridyl)thiazolyl Chalcones and Pyrazolines. Russ J Gen Chem 91, 488–494 (2021). https://doi.org/10.1134/S1070363221030178

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