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Synthesis and Anticancer Activity of New Thiophene, Thiazolyl-Thiophene, and Thienopyridine Derivatives

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Abstract

New 4-acetyl-5-anilino-N-arylthiophene-2-carboxamide derivatives have been synthesized by reaction of 2-acetyl-3-oxo-N-phenylbutanethioamide with three different chloroacetamide reagents. The synthesized thiophenes have been used as precursors in preparation of various thiazole-thiophene hybrids via their condensation with thiosemicarbazide and following treatment of the corresponding thiosemicarbazone with chloroacetone and/or chloroacetic acid. The reaction of 4-acetyl-5-anilinothiophenes with DMF–DMA or malononitrile is the synthetic route to the targeted thieno[2,3-b]pyridine derivatives. Molecular structures of the synthesized compounds have been determined on the basis of IR, 1H and 13C NMR, and mass spectra. The synthesized thiophene-based compounds have been tested for in vitro cytotoxicity by the MTT assay using 5-flourouracil as a reference drug. Thiophene-2-carboxamide derivatives exhibit good inhibitory activity against four cell lines, especially those products that contain thiazolidinone ring or thiosemicarbazide moiety in their structures.

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ACKNOWLEDGMENTS

The authors would like to extend their sincere appreciation to Researchers Supporting Project Number (RSP-2020/63), King Saud University, Riyadh, Saudi Arabia.

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Correspondence to E. Abdel-Latif.

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Atta, A.M., Abdel-Latif, E. Synthesis and Anticancer Activity of New Thiophene, Thiazolyl-Thiophene, and Thienopyridine Derivatives. Russ J Gen Chem 91, 456–463 (2021). https://doi.org/10.1134/S1070363221030154

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