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Synthesis of the Gold Glyconanoparticles Based on 6-Deoxy- and 2-(Acetylamino)aldoses 3-Thiopropionylhydrazones

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Abstract

A method for the synthesis of gold glyconanoparticles with average particle size of 18–21 nm and low polydispersity index based on readily available thiolated compounds: 3-thiopropionylhydrazones of L-fucose, L-rhamnose, N-acetyl-D-glucosamine, and N-acetyl-D-mannosamine has been developed. It has been shown that some of the gold glyconanoparticles exhibit antitumor activity, and the initial thiolated glycoligands have shown strong radioprotective activity, increasing the survival rate of mortally irradiated mice by 50–70%.

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Authors and Affiliations

  1. Institute of Macromolecular Compounds of the Russian Academy of Sciences, 199004, St. Petersburg, Russia

    A. Yu. Ershov, A. A. Martynenkov & A. V. Yakimansky

  2. State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, 195043, St. Petersburg, Russia

    I. V. Lagoda & E. A. Yakunchikova

  3. Ryazan Medical University named after I.P. Pavlov, 390026, Ryazan, Russia

    M. A. Kopanitsa & I. V. Chernykh

  4. St. Petersburg State University, 199034, St. Petersburg, Russia

    A. V. Yakimansky

Authors
  1. A. Yu. Ershov
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  2. A. A. Martynenkov
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  3. I. V. Lagoda
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  4. E. A. Yakunchikova
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Correspondence to A. Yu. Ershov.

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Translated from Zhurnal Obshchei Khimii, 2021, Vol. 91, No. 2, pp. 260–268 https://doi.org/10.31857/S0044460X21020098.

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Ershov, A.Y., Martynenkov, A.A., Lagoda, I.V. et al. Synthesis of the Gold Glyconanoparticles Based on 6-Deoxy- and 2-(Acetylamino)aldoses 3-Thiopropionylhydrazones. Russ J Gen Chem 91, 215–222 (2021). https://doi.org/10.1134/S1070363221020092

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