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Synthesis of Novel 4ʹ-Hydroxy-2ʹ,3-diaryl-3,4,4ʹ,5ʹ-tetrahydro-2H,2ʹH,6H-spiro[thiazolo[3,2-a][1,3,5]triazine-7,3ʹ-thiophen]-6-one Derivatives via Sulfa-Michael/Aldol Cascade Reactions

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Abstract

The sulfa-Michael/aldol cascade reaction of (Z)-7-arylidene -3-aryl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-6(7H)-one with 1,4-dithiane-2,5-diol leads to novel 4ʹ-hydroxy-2ʹ,3-diaryl-3,4,4ʹ,5ʹ-tetrahydro-2H,2ʹH,6H-spiro[thiazolo[3,2-a][1,3,5]triazine-7,3ʹ-thiophen]-6-ones in moderate yields. Structures of all the products are characterized by NMR, IR, and HRMS spectra in combination with X-ray crystallographic analysis.

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ACKNOWLEDGMENTS

We are grateful to the National Natural Science Foundation of China (No. 21671063) for the financial support.

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  1. Key Laboratory of Theoretical Organic Chemistry and Functional Molecules, Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, 411201, Hunan, Xiangtan Taoyuan Road, China

    Sha Li, Jiaxi Tan & Xiaofang Li

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  1. Sha Li
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  2. Jiaxi Tan
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  3. Xiaofang Li
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Correspondence to Xiaofang Li.

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Li, S., Tan, J. & Li, X. Synthesis of Novel 4ʹ-Hydroxy-2ʹ,3-diaryl-3,4,4ʹ,5ʹ-tetrahydro-2H,2ʹH,6H-spiro[thiazolo[3,2-a][1,3,5]triazine-7,3ʹ-thiophen]-6-one Derivatives via Sulfa-Michael/Aldol Cascade Reactions. Russ J Gen Chem 91, 128–132 (2021). https://doi.org/10.1134/S1070363221010151

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