Abstract
Depending on the ring size in the Reformatsky reagent and the nature of substituents in arylmethylidene fragment, the reactions of Reformatsky reagents obtained from methyl esters of 1-bromocycloalkanecarboxylic acids and zinc with N′-(arylmethylidene)-2-oxo-2H-chromene-3-carbohydrazides afforded methyl 1-{3-[2-(arylmethylidene)hydrazinylcarbonyl]-2-oxochroman-4-yl}cycloalkanecarboxylates or methyl 1-{3-[(3-aryl-1-oxo-2-azaspiro[3.5]nonan-2-yl)carbamoyl]-2-oxochroman-4-yl}cyclohexanecarboxylates. The resulting compounds exhibit antinociceptive activity.
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This work was financially supported by the Government of the Perm Region.
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Nikiforova, E.A., Makhmudov, R.R., Rudin, A.A. et al. Reaction of N′-(Arylmethylidene)-2-oxo-2H-chromene-3-carbohydrazides with Methyl 1-Bromocycloalkanecarboxylates and Zinc. Russ J Gen Chem 91, 64–71 (2021). https://doi.org/10.1134/S1070363221010060
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DOI: https://doi.org/10.1134/S1070363221010060