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Synthesis and Anticancer Activity of Different 1,2,4-Triazolearyl Incorporated Thiazolepyridine Derivatives

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Abstract

A number of novel thiazolepyridine combined with 1,2,4-triazolyl residue derivatives in the molecular structures has been designed, synthesized and characterized by spectroscopic methods. The products have been tested for their anticancer activity against human cancer lines PC3, DU-145 (prostate cancer), A549 (lung cancer), and MCF-7 (breast cancer) by the MTT assay using etoposide as a positive control. Most of compounds have exhibited distinctive anticancer activity on four cell lines. Four of those have been determined to be more potent than etoposide.

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ACKNOWLEDGMENTS

The author is thankful to JNT University-Hyderabad for constant encouragement during this research program. The author is also thankful to Green Evolution Laboratories for providing necessary facility for research work.

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Authors and Affiliations

  1. Department of Chemistry, Jawaharlal Nehru Technological University , 500072, Hyderabad, Telangana, India

    Sanivarapu Sumalatha

  2. Green Evolution Laboratories, Wangapally Village, 508286, Nalgonda, Telangana, India

    Sanivarapu Sumalatha

  3. Department of Chemistry, Satavahana University, 505002, Karimnagar, Telangana, India

    V. Namrata

  4. Department of Life Sciences, Kakatiya University, 506009, Warangal, Telangana, India

    Marepally Lakshmi

  5. Department of Chemistry, Kakatiya Institute of Technology and Science, 506015, Warangal, India

    Gattu Sridhar

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  1. Sanivarapu Sumalatha
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  2. V. Namrata
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  3. Marepally Lakshmi
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  4. Gattu Sridhar
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Correspondence to Sanivarapu Sumalatha.

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Sumalatha, S., Namrata, V., Lakshmi, M. et al. Synthesis and Anticancer Activity of Different 1,2,4-Triazolearyl Incorporated Thiazolepyridine Derivatives. Russ J Gen Chem 90, 2381–2385 (2020). https://doi.org/10.1134/S1070363220120245

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  • DOI: https://doi.org/10.1134/S1070363220120245

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