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Supramolecular Complex of 20-Hydroxyecdysone-3-acetate with β-Cyclodextrin and Its Biological Activity

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Abstract

In order to obtain new potentially bioactive substances and to investigate the effect of bulky functional groups on the formation of supramolecular complexes, 20-hydroxyecdysone triacetate has been synthesized, its spatial structure has been determined, and its complexation with β-cyclodextrin has been studied by means of NMR. The anti-inflammatory activity of the obtained water-soluble complex has been assessed.

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Funding

This study was financially supported by the Committee for Science of the Ministry of Education and Science of Kazakhstan (grant АР05133718 “Synthesis, Structure and Biological Activity of Novel Water-Soluble Derivatives of Polyoxysteroids”).

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Authors and Affiliations

  1. International Scientific and Production Holding “Phytochemistry”, 100009, Karaganda, Kazakhstan

    B. I. Tuleuov, B. S. Temirgaziev, A. M. Kozhanova, R. B. Seydakhmetova & S. M. Adekenov

  2. E.A. Buketov Karaganda State University, 100028, Karaganda, Kazakhstan

    B. S. Temirgaziev & K. M. Turdybekov

  3. Sh. Ualikhanov Kokshetau State University, 020000, Kokshetau, Kazakhstan

    T. M. Seilkhanov & O. T. Seilkhanov

  4. University of Chemistry and Technology, 16628, Prague, Czech Republic

    P. Drasar

Authors
  1. B. I. Tuleuov
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  2. B. S. Temirgaziev
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  3. A. M. Kozhanova
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  4. R. B. Seydakhmetova
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  5. K. M. Turdybekov
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  6. T. M. Seilkhanov
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  7. O. T. Seilkhanov
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  8. P. Drasar
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  9. S. M. Adekenov
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Correspondence to B. I. Tuleuov.

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Tuleuov, B.I., Temirgaziev, B.S., Kozhanova, A.M. et al. Supramolecular Complex of 20-Hydroxyecdysone-3-acetate with β-Cyclodextrin and Its Biological Activity. Russ J Gen Chem 90, 2258–2263 (2020). https://doi.org/10.1134/S1070363220120075

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