Abstract
A novel series of imidazo [1,2-a]pyridine derivatives has been designed, synthesized and tested for the anti-proliferative activity against three different human cancer cell lines. Most of the synthesized compounds exhibit anti-proliferative activity with IC50 values ranging from 5.35–59.8 μM. Six compounds demonstrate efficient inhibition of growth of all cell lines with IC50 values close to that of standard drug, and the compound 16h is more potent than the standard drug cisplatin for the HeLa cell line.
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ACKNOWLEDGMENTS
The authors would like to thank the management of AMRI Hyderabad research centre for giving an opportunity to carry out this research. The authors are also thankful to SaiInnotech labs Pvt.Ltd.for providing synthesis facility.
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Endoori, S., Gulipalli, K.C., Bodige, S. et al. Design, Synthesis, Anti-Cancer Activity, and in silico Studies of Novel Imidazo[1,2-a]pyridine Derivatives. Russ J Gen Chem 90, 1727–1736 (2020). https://doi.org/10.1134/S1070363220090212
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DOI: https://doi.org/10.1134/S1070363220090212