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Synthesis and Antimicrobial Activity of (3-Formyl-4-hydroxybenzyl)triphenylphosphonium Chloride Acylhydrazones

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Abstract

In this study, four novel quaternary phosphonium acylhydrazones, derivatives of (3-formyl-4-hydroxybenzyl)triphenylphosphonium chloride, have been synthesized and their structures elucidated from IR and NMR spectra, and elemental analysis. All synthesized compounds have been tested for their antimicrobial activity, and acylhydrazones have demonstrated selective activity against Gram-positive bacteria strains.

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Funding

This work was financially supported by the Serbian Ministry of Education, Science and Technological Development (grant no. 451-03-68/2020-14/200026).

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Authors and Affiliations

  1. Faculty of Chemistry, University of Belgrade, 11000, Belgrade, Serbia

    M. R. Milenković & V. Živković-Radovanović

  2. University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, 11000, Belgrade, Serbia

    L. Andjelković

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  1. M. R. Milenković
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  2. V. Živković-Radovanović
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  3. L. Andjelković
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Correspondence to L. Andjelković.

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Milenković, M.R., Živković-Radovanović, V. & Andjelković, L. Synthesis and Antimicrobial Activity of (3-Formyl-4-hydroxybenzyl)triphenylphosphonium Chloride Acylhydrazones. Russ J Gen Chem 90, 1716–1720 (2020). https://doi.org/10.1134/S1070363220090194

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