Abstract
A number of new pyrazole and pyrimidine derivatives containing an allylmorpholine fragment were obtained by reactions of chromone-containing allylmorpholines with 1,2- and 1,3-binucleophiles (hydrazine, guanidine, acetamidine). The syntheses were carried out under mild conditions (ethanol, room temperature), and the target products were isolated with high yields. The obtained compounds are of interest as potential cholinesterase inhibitors.
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This work was supported of the Council for Grants of the President of the Russian Federation (SP-2019).
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Chernov, N.M., Ezhov, P.I., Shutov, R.V. et al. Synthesis of 1-[3-(Hetaryl)allyl]morpholines as Potential Anticholinesterase Agents. Russ J Gen Chem 90, 1620–1624 (2020). https://doi.org/10.1134/S1070363220090054
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DOI: https://doi.org/10.1134/S1070363220090054