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Peroxo Complexes of Th(IV) and Zr(IV) Ions Containing Aspartic Acid and Amine Bases as Potential Biological Agents

Russian Journal of General Chemistry volume 90, pages 1553–1557 (2020)Cite this article

Abstract

Eight new peroxo complexes of the type [MO(O2)(Asp)L] have been synthesized and characterized by conductivity, magnetic moments, UV-Vis, IR, ESI-MS and 1H NMR spectra, TLC, and elemental analyses [M = Th(IV) and Zr(IV), Asp= deprotonated aspartic acid, L = quinoline, isoquinoline, 8-hydroxyquinoline, and 1,10-phenanthroline]. IR spectra indicate that the ligands coordinate to the metal ions via nitrogen of the amino group of aspartic acid and heterocyclic amines, oxygen of the carboxylate group of deprotonated aspartic acid and the peroxo group (O–O). ESI-MS spectral data and magnetic moment values coupled with electronic spectral data suggest an octahedral geometry for all the complexes. The molar conductance values indicate that all the complexes behave as 1 : 2 electrolytes except complexes of 8-hydroxyquinoline that behaves as 1 : 3 electrolytes. Antibacterial activity of the complexes has been tested against four pathogenic bacteria, two Gram-positive Staphylococcus aureus and Bacillus subtilis and two Gram-negative Escherichia coli and Shigella dysenteriae using Kanamycin (K-30) as a standard. The MIC values for complexes hve been measured. Antifungal activity of the complexes has been tested against four pathogenic fungi Aspergillus flavus, Penicillium species, Candida species, and Aspergillus niger using Fluconazole-50 as a standard. The complexes K2[ThO(O2)(Asp)(IQ)] and K2[ZrO(O2)(Asp)(Q)] demonstrate the highest antibacterial activity, and K2[ZrO(O2)(Asp)(1,10-Phen)] exhibits the highest antifungal activity against all the tested pathogens.

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ACKNOWLEDGMENTS

The authors are thankful to the Chairman, Department of Chemistry, University of Rajshahi, Bangladesh for the laboratory facilities. Also, grateful to the Ministry of Science and Technology, Peoples Republic of Bangladesh for their financial support.

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Authors and Affiliations

  1. Department of Chemistry, University of Rajshahi, 6205, Rajshahi, Bangladesh

    N. A. Bitu, A. Kader, M. S. Islam, M. M. Haque, F. Hossen, A. Asraf &  Kudrat-E-Zahan

  2. Department of Chemistry, Begum Rokeya University, 5400, Rangpur, Bangladesh

    S. Hossain

  3. Chemistry Discipline, Khulna University, 9208, Khulna, Bangladesh

    N. Islam

  4. Department of Chemistry, Government College of Engineering, Keonjhar, 758002, Odisha, India

    R. K. Mohapatra

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  1. N. A. Bitu
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Bitu, N.A., Hossain, S., Islam, N. et al. Peroxo Complexes of Th(IV) and Zr(IV) Ions Containing Aspartic Acid and Amine Bases as Potential Biological Agents. Russ J Gen Chem 90, 1553–1557 (2020). https://doi.org/10.1134/S1070363220080253

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  • DOI: https://doi.org/10.1134/S1070363220080253

Keywords:

  • peroxo complexes
  • aspartic acid
  • heterocyclic amines
  • antibacterial activity
  • MIC
  • antifungal activity