Eight new peroxo complexes of the type [MO(O2)(Asp)L] have been synthesized and characterized by conductivity, magnetic moments, UV-Vis, IR, ESI-MS and 1H NMR spectra, TLC, and elemental analyses [M = Th(IV) and Zr(IV), Asp= deprotonated aspartic acid, L = quinoline, isoquinoline, 8-hydroxyquinoline, and 1,10-phenanthroline]. IR spectra indicate that the ligands coordinate to the metal ions via nitrogen of the amino group of aspartic acid and heterocyclic amines, oxygen of the carboxylate group of deprotonated aspartic acid and the peroxo group (O–O). ESI-MS spectral data and magnetic moment values coupled with electronic spectral data suggest an octahedral geometry for all the complexes. The molar conductance values indicate that all the complexes behave as 1 : 2 electrolytes except complexes of 8-hydroxyquinoline that behaves as 1 : 3 electrolytes. Antibacterial activity of the complexes has been tested against four pathogenic bacteria, two Gram-positive Staphylococcus aureus and Bacillus subtilis and two Gram-negative Escherichia coli and Shigella dysenteriae using Kanamycin (K-30) as a standard. The MIC values for complexes hve been measured. Antifungal activity of the complexes has been tested against four pathogenic fungi Aspergillus flavus, Penicillium species, Candida species, and Aspergillus niger using Fluconazole-50 as a standard. The complexes K2[ThO(O2)(Asp)(IQ)] and K2[ZrO(O2)(Asp)(Q)] demonstrate the highest antibacterial activity, and K2[ZrO(O2)(Asp)(1,10-Phen)] exhibits the highest antifungal activity against all the tested pathogens.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Salles, L., Piquemal, J.Y., Thouvenot, R., Minot, C., and Bregeault, J.M., J. Mol. Catal. A: Chemical, 1997, vol. 117, nos. 1–3, p. 375. https://doi.org/10.1016/S1381-1169(96)00257-9
Herrmann, W.A., Correia, J.D.G., Artus, G.R.J., Fischer, R.W., and Romao, C.C., J. Organometal. Chem., 1996, vol. 520, nos. 1–2, p. 139. https://doi.org/10.1016/0022-328X(96)06272-9
Tarafder, M.T.H., Bhattacharjee, P., and Sarkar, A.K., Polyhedron, 1992, vol. 11, no. 7, p. 795. https://doi.org/10.1016/S0277-5387(00)86012-X
Tarafder, M.T.H. and Khan, A.R., Polyhedron, 1991, vol. 10, no. 8, p. 819. https://doi.org/10.1016/S0277-5387(00)86114-8
Agarwal, D.D., Srivastava, S., and Chadha, P., Polyhedron, 1990, vol. 9, no. 11, p. 1401. https://doi.org/10.1016/S0277-5387(00)84023-1
Kurosawa, H., Achiha, T., Kajimaru, H., and Ikeda, I., Inorg. Chim. Acta, 1991, vol. 190, no. 2, p. 271. https://doi.org/10.1016/S0020-1693(00)80264-9
Djordjevic, C., Vuletic, N., and Puryear, B.C., J. Inorg. Biochem., 1993, vol. 51, nos. 1–2, p. 308. https://doi.org/10.1016/0162-0134(93)85340-E
Shinohara, N., Matsufuji, S., and Okubo, W., Polyhedron, 1991, vol. 10, no. 1, p. 107. https://doi.org/10.1016/S0277-5387(00)83556-1
Fujisawa, K., Katayama, T., Kitajima, N., and Morooka, Y., J. Inorg. Biochem, 1991, vol. 43, nos. 2–3, p. 216. https://doi.org/10.1016/0162-0134(91)84208-Q
Schmidt, H., Anderson, I., Rehder, D. and Peterson, L.A., Chemistry–A Eur. J., 2001, vol. 7, no. 1, p. 251. https://doi.org/10.1002/1521-3765(20010105)7:1<251::AID-CHEM251>3.0.CO;2-9
Kudrat-E-Zahan, Hossain, S., Haque, M.M., Banu, L.A., Matin, M.A., Bitu, .N.A., Habib, A., Ashrafuzzaman, Uddin, N., and Islam, M.S., Biochem. Mol. Biol., 2019, vol. 4, no. 3, p. 35. https://doi.org/10.11648/j.bmb.20190403.11
El-Barasi, N.M., Miloud, M.M., El-ajaily, M.M., Mohapatra, R.K., Sarangi, A.K., Das, D., Mahal, A., Parhi, P.K., Pintilie, L., Barik, S.R., Bitu, M.N.A, Kudrat-E-Zahan, M., Tabassum, Z., Al Resayes, S.I., and Azam, M., J. Saudi Chem. Soc., 2020, https://doi.org/10.1016/j.jscs.2020.04.00
Latif, M.A., Tofaz, T., Chaki, B.M., Tariqul Islam, H.M., Hossain, M.S., and Kudrat-E-Zahan, M., Russ. J. Gen. Chem., 2019, vol. 89, no. 6, p. 1197. https://doi.org/10.1134/S107036321906015X
Kudrat-E-Zahan, M., Islam, M.S., and Bashar, M.A., Russ. J. Gen. Chem., 2015, vol. 85, no. 3, p. 667. https://doi.org/10.1134/S1070363215030238
Elachi, K.A., Hossain, M.S., Bitu, M.N.A., Zahid, A.A.S.M., Mohapatra, R.K., Mannan, M.A., Zakaria, C.M., and Kudrat-E-Zahan, M., J. Chem. Biol. Phys. Sci., Sect. A, 2019, vol. 9, no. 4, p. 201. https://doi.org/10.24214/jcbps.A.9.4.20118
The authors are thankful to the Chairman, Department of Chemistry, University of Rajshahi, Bangladesh for the laboratory facilities. Also, grateful to the Ministry of Science and Technology, Peoples Republic of Bangladesh for their financial support.
No conflict of interest was declared by the authors.
Rights and permissions
About this article
Cite this article
Bitu, N.A., Hossain, S., Islam, N. et al. Peroxo Complexes of Th(IV) and Zr(IV) Ions Containing Aspartic Acid and Amine Bases as Potential Biological Agents. Russ J Gen Chem 90, 1553–1557 (2020). https://doi.org/10.1134/S1070363220080253
- peroxo complexes
- aspartic acid
- heterocyclic amines
- antibacterial activity
- antifungal activity