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Synthesis, Antimicrobial Evaluation, and Molecular Docking Study of New Thiazole-5-phenylpropenone Derivatives

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Abstract

A series of new (E)-1-[2-(2-ethylpyridin-4-yl)-4-methylthiazol-5-yl]-3-phenylprop-2-en-1-one derivatives have been synthesized starting from the antitubercular drug, ethionamide. The synthesized compounds have been tested for their in vitro antimicrobial activity, and five of those have demonstrated promising activity. According to molecular docking study the active compounds have display high binding affinity towards DNA Gyrase and Lumazine Synthase.

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Funding

This study was funded by Dr. Babasaheb Ambedkar Marathwada University Aurangabad (grant no. MRP STAT/V1/RG/Dept/2019-20/323-324).

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Authors and Affiliations

  1. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University SubCampus, 413501, Osmanabad, India

    P. S. Patil, S. L. Kasare, A. D. Badar, R. S. Kulkarni & K. P. Haval

  2. Department of Microbiology, Dr. Babasaheb Ambedkar Marathwada University SubCampus, 413501, Osmanabad, India

    P. P. Dixit

  3. Department of Biotechnology, Dr. Babasaheb Ambedkar Marathwada University SubCampus, 413501, Osmanabad, India

    J. A. Kulkarni

  4. Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, 416013, Kolhapur, India

    P. B. Choudhari

Authors
  1. P. S. Patil
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  2. S. L. Kasare
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  3. A. D. Badar
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  4. R. S. Kulkarni
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  5. P. P. Dixit
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  6. J. A. Kulkarni
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  7. P. B. Choudhari
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  8. K. P. Haval
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Correspondence to K. P. Haval.

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Patil, P.S., Kasare, S.L., Badar, A.D. et al. Synthesis, Antimicrobial Evaluation, and Molecular Docking Study of New Thiazole-5-phenylpropenone Derivatives. Russ J Gen Chem 90, 1523–1528 (2020). https://doi.org/10.1134/S1070363220080216

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  • DOI: https://doi.org/10.1134/S1070363220080216

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