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Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones

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Abstract

The reaction of tryptamine with aromatic aldehydes and 4-chlorobenzoylpyruvic acid methyl ester led to the formation of 5-aryl-4-[hydroxy-(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones. The resulting compounds were tested for antimicrobial activity.

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Funding

This work was supported by the St. Petersburg State University (Application for the development of the material and technical base of St. Petersburg State University no. 33402376) using the equipment of the resource centers of the Scientific Park of St. Petersburg State University “Chemistry Educational Center,” “Chemical Analysis and Materials Research Center,” “SPbU Computing Center,” “Center for Optical and Laser Materials Research,” and “Magnetic Resonance Research Center.”

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, 614990, Perm, Russia

    V. L. Gein, L. I. Varkentin, T. M. Zamaraeva & V. V. Novikova

  2. E.A. Vagner Perm State Medical University, 614990, Perm, Russia

    M. I. Kazantseva

  3. ITMO University, 197101, St. Petersburg, Russia

    A. N. Yankin

  4. St. Petersburg State University, 199034, St. Petersburg, Russia

    E. V. Beletskii

Authors
  1. V. L. Gein
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  2. M. I. Kazantseva
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  3. L. I. Varkentin
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  4. T. M. Zamaraeva
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  5. A. N. Yankin
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  6. E. V. Beletskii
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  7. V. V. Novikova
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Correspondence to V. L. Gein.

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Gein, V.L., Kazantseva, M.I., Varkentin, L.I. et al. Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones. Russ J Gen Chem 90, 1426–1431 (2020). https://doi.org/10.1134/S1070363220080083

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