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N-Hydroxymethylation of 3-Aryl-2-cyanoprop-2-enethioamides

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Abstract

Hydroxymethylation of (E)-3-aryl-2-cyanoprop-2-enethioamides with an aqueous alcoholic solution of formaldehyde has afforded (E)-3-aryl-N-(hydroxymethyl)-2-cyanoprop-2-enethioamides. The predictive analysis of the biological activity of the obtained compounds in silico has been carried out.

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Funding

This study was financially supported by the Ministry of Education and Science of Russian Federation (project no. 0795-2020-0031).

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Authors and Affiliations

  1. Kuban State University, 350040, Krasnodar, Russia

    V. V. Dotsenko & S. G. Krivokolysko

  2. North Caucasus Federal University, 355009, Stavropol, Russia

    V. V. Dotsenko

  3. National Research Center “Kurchatov Institute”–IREA, 107076, Moscow, Russia

    E. A. Chigorina

  4. National Research Center “Kurchatov Institute”, 123182, Moscow, Russia

    E. A. Chigorina

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  1. V. V. Dotsenko
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  2. E. A. Chigorina
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  3. S. G. Krivokolysko
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Dotsenko, V.V., Chigorina, E.A. & Krivokolysko, S.G. N-Hydroxymethylation of 3-Aryl-2-cyanoprop-2-enethioamides. Russ J Gen Chem 90, 1411–1417 (2020). https://doi.org/10.1134/S107036322008006X

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