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Synthesis and Insecticidal Activity of β-D-Ribofuranoside Phosphate Derivatives

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Abstract

Phosphorylation of 4-methylphenyl 2,3-di-O-benzoyl-1-thio-β-D-ribofuranoside, followed by removal of the benzoyl protection afforded 1-S-(4-methylphenyl)-1-thio-β-D-ribofuranoside 5-phosphates. The synthesized compounds showed insecticidal activity against the vetch aphid Megoura viciae Buckt in combination with low toxicity.

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Authors and Affiliations

  1. Schulich Faculty of Chemistry, Technion—Israel Institute of Technology, 3200008, Haifa, Israel

    V. V. Belakhov

  2. Microbiological Plant Protection Laboratory, All-Russian Institute of Plant Protection, 196608, St. Petersburg, Russia

    I. V. Boikova & I. L. Krasnobaeva

  3. Department of Biotechnology, St. Petersburg State Chemical-Pharmaceutical University, 197376, St. Petersburg, Russia

    V. A. Kolodyaznaya

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  1. V. V. Belakhov
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  2. I. V. Boikova
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  3. I. L. Krasnobaeva
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  4. V. A. Kolodyaznaya
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Correspondence to V. V. Belakhov.

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Belakhov, V.V., Boikova, I.V., Krasnobaeva, I.L. et al. Synthesis and Insecticidal Activity of β-D-Ribofuranoside Phosphate Derivatives. Russ J Gen Chem 90, 1249–1254 (2020). https://doi.org/10.1134/S1070363220070129

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