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Synthesis of 5-Aryl(heteryl)-1-hydroxyethyl-4-(furyl-2-carbonyl)-3-hydroxy-3-pyrroline-2-ones

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Abstract

5-Aryl(heteryl)-1-hydroxyethyl-4-(furyl-2-carbonyl)-3-hydroxy-3-pyrroline-2-ones were synthesized via reactions of methyl ester of furyl-2-carbonylpyruvic acid with a mixture of aromatic or heterocyclic aldehyde and ethanolamine in dioxane. Antibacterial and antifungal activities of the synthesized compounds was studied.

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REFERENCES

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, 614990, Perm, Russia

    V. L. Gein, D. D. Rubtsova & A. A. Bobyleva

  2. National Research University ITMO, 197101, St. Petersburg, Russia

    A. N. Yankin

Authors
  1. V. L. Gein
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  2. D. D. Rubtsova
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  3. A. A. Bobyleva
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  4. A. N. Yankin
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Corresponding author

Correspondence to V. L. Gein.

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No conflict of interest was declared by the authors. This work has been completed in compliance with all applicable international, national, and institutional guidelines for the care and use of animals.

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Gein, V.L., Rubtsova, D.D., Bobyleva, A.A. et al. Synthesis of 5-Aryl(heteryl)-1-hydroxyethyl-4-(furyl-2-carbonyl)-3-hydroxy-3-pyrroline-2-ones. Russ J Gen Chem 90, 804–808 (2020). https://doi.org/10.1134/S1070363220050072

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  • DOI: https://doi.org/10.1134/S1070363220050072

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