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New Bis-4H-1,2,4-triazoles and Their In Vitro Study as DNA Methylation Inhibitors

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Abstract

Bis-1,2,4-triazoles with aryl and alkyl linkers were synthesized. In order to increase their hydrophilicity and potential biological activity, pharmacophore electron-deficient groups (carboxylic, carboxamide, nitrile) were introduced into the molecule. Functionalized compounds revealed a new type of biological activity such as inhibition of the level of methylation of tumor DNA.

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Authors and Affiliations

  1. Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, 0014, Yerevan, Armenia

    S. V. Dilanyan, T. R. Hovsepyan, L. E. Nersesyan, A. S. Agaronyan, I. S. Danielyan, N. S. Minasyan & A. A. Harutyunyan

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  1. S. V. Dilanyan
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  2. T. R. Hovsepyan
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  3. L. E. Nersesyan
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  4. A. S. Agaronyan
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  5. I. S. Danielyan
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  6. N. S. Minasyan
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  7. A. A. Harutyunyan
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Correspondence to A. A. Harutyunyan.

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Dilanyan, S.V., Hovsepyan, T.R., Nersesyan, L.E. et al. New Bis-4H-1,2,4-triazoles and Their In Vitro Study as DNA Methylation Inhibitors. Russ J Gen Chem 90, 787–793 (2020). https://doi.org/10.1134/S1070363220050047

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  • DOI: https://doi.org/10.1134/S1070363220050047

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