Abstract
A novel series of quinazolin-4(3H)-one derivatives has been synthesized in high yields using the multicomponent Ugi reaction and characterized by IR, NMR and mass spectral data. The products have been tested for their cytotoxic activity against HeLa cells. Two tested compounds have shown potent activity compared to standard drug Doxorubicin. The in silico docking studies of the compounds against quinone reductase-2 (4ZVM) enzyme have also supported their activity.
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ACKNOWLEDGMENTS
P. Shankaraiah thanks to UGC, New Delhi, India for providing research fellowship and Department of chemistry, Osmania University for providing research facilities.
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Shankaraiah, P., Bhavani, A.K.D., Kumar, A.K. et al. Synthesis and Cytotoxicity of Quinazolin-4(3H)-one Based Peptides. Russ J Gen Chem 90, 720–724 (2020). https://doi.org/10.1134/S1070363220040246
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DOI: https://doi.org/10.1134/S1070363220040246