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Synthesis and Cytotoxicity of Chalcone Based 1,2,3-Triazole Derivatives

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Abstract

Synthesis of a novel series of chalcone based 1,2,3-triazole derivatives and their anti-cancer studies are presented. Majority of the target compounds exhibit moderate to excellent activity against A-549 cells. Among the compounds screened 7c and 7j demonstrate potent activity being compared with the standard drug Doxorubicin.

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ACKNOWLEDGMENTS

M. Raghavender thanks the Head of the Department, Osmania University, Hyderabad, India and Central Facilities for Research and Development, Osmania University, Hyderabad, India for providing analytical support.

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Authors and Affiliations

  1. Department of Chemistry, University College of Science, Osmania University, Hyderabad, 500007, Telangana, India

    M. Raghavender, V. Sunitha & P. Jalapathi

  2. Department of Humanities and Sciences, Vardhaman College of Engineering, 501218, Hyderabad, India

    A. Kishore Kumar

  3. Department of Sciences and Humanities, Matrusri Engineering College, Saidabad, 500059, Hyderabad, India

    T. Vishnu

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  1. M. Raghavender
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  2. A. Kishore Kumar
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  3. V. Sunitha
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  5. P. Jalapathi
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Correspondence to P. Jalapathi.

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Raghavender, M., Kumar, A.K., Sunitha, V. et al. Synthesis and Cytotoxicity of Chalcone Based 1,2,3-Triazole Derivatives. Russ J Gen Chem 90, 697–702 (2020). https://doi.org/10.1134/S1070363220040210

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