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Synthesis and Plant Growth Stimulating Action of 2-Amino-6-methylpyrimidine-4(3H)-thione Derivatives

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Abstract

A series of new pyrimidine derivatives, including those containing an azole or azine heterocycle linked through a sulfur atom or a thiomethylene group, was synthesized based on 2-amino-6-methylpyrimidine-4(3H)-thione. The synthesized compounds exhibited a pronounced stimulating effect on plants growth in the range of 43–96% compared to heteroauxin.

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REFERENCES

  1. Mashkovskii, M.D., Lekarstvennye sredstva (Drugs), Moscow: Novaya Volna, 2002.

  2. Koroleva, E.V., Gusak, K.N., and Ignatovich, Zh.V., Russ. Chem. Rev., 2010, vol. 79, p. 655. https://doi.org/10.1070/RC2010v079n08ABEH004116

    Article  CAS  Google Scholar 

  3. Kraljević, T.G., Ilić, N., Stepanić, V., Sappe, L., Petranović, J., Pavelić, S.K., and Raić-Malić, S., Bioorg. Med. Chem. Lett., 2014, vol. 24, p. 2913. https://doi.org/10.1016/j.bmcl.2014.04.079

    Article  CAS  Google Scholar 

  4. Ghorab, M.M., Ragab, F.A., Alqasoumi, S.I., Alafeefy, A.M., and Aboulmagd, S.A., Eur. J. Med. Chem., 2010, vol. 45, p. 171. https://doi.org/10.1016/j.ejmech.2009.09.039

    Article  CAS  PubMed  Google Scholar 

  5. Goudar, V., Rashmi, P., Shantharam, U., Hazra, K., and Nargund, L.G., J. Chem. Pharm. Res., 2012, vol. 4, p. 3100.

    CAS  Google Scholar 

  6. Kumaresan, S., Chandrasekaran, S., Sakthivel, K.M., Guruvayoorappan, C., and Enoch, I.V.M., J. Chem. Pharm. Res., 2014, vol. 6, p. 593.

    Google Scholar 

  7. Kaur, N., Aggarwal, A.K., Sharma, N., and Choudhary, B., Int. J. Pharm. Sci. Drug Res., 2012, vol. 4, p. 199.

    CAS  Google Scholar 

  8. Patel, D.H., Chikhalia, K.H., Shah, N.K., Patel, D.P., Kaswala, P.B., and Buha, V.M., Pharm. Chem. J., 2010, vol. 44, p. 94. https://doi.org/10.1007/s11094-010-0406-9

    Article  CAS  Google Scholar 

  9. Moustafa, A.H., Saad, H., Shehab, W., and ElMobayed, M.M., Phosphorus, Sulfur, Silicon, Relat. Elem., 2007, vol. 183, p. 115. https://doi.org/10.1080/10426500701557286

    Article  CAS  Google Scholar 

  10. Ingarsal, N., Saravanan, G., Amutha, P., and Nagarajan, S., Eur. J. Med. Chem., 2007, vol. 42, p. 517. https://doi.org/10.1016/j.ejmech.2006.09.012

    Article  CAS  PubMed  Google Scholar 

  11. Kanagarajan, V., Thanusu, J., and Gopalakrishnan, M.A., J. Korean Chem. Soc., 2009, vol. 53, p. 731. https://doi.org/10.5012/jkcs.2009.53.6.731

    Article  CAS  Google Scholar 

  12. Wang, S.C., Gao, J.-G., Zhang, S., Liu, S., and Jiang, L., Phosphorus, Sulfur, Silicon, Relat. Elem., 2018, vol. 193, p. 245. https://doi.org/10.1080/10426507.2017.1395439

    Article  CAS  Google Scholar 

  13. Holy, A., Votruba, I., Masojìdkova, M., Andrei, G., Snoeck, R., Naesens, L., De Clercq, E., and Balzarini, J., J. Med. Chem., 2002, vol. 45, p. 1918. https://doi.org/10.1021/jm011095y

    Article  CAS  PubMed  Google Scholar 

  14. Dalkara, S., Karakurt, A., Curr. Top. Med. Chem., 2012, vol. 12, p. 1033. doi 10.2174/156802612800229215

    Article  CAS  Google Scholar 

  15. Abu-Hashem, A.A., Youssef, M.M., and Hussein, H.A.R., J. Chin. Chem. Soc., 2011, vol. 58, p. 41. https://doi.org/10.1002/jccs.201190056

    Article  CAS  Google Scholar 

  16. Abu-Hashem, A.A., El-Shehry, M.F., and Badria, F.A., Act. Pharm., 2010, vol. 60, p. 311. doi 10.2478/v10007-010-0027-6

    CAS  Google Scholar 

  17. Sakakibara, N., Hamasaki, T., Baba, M., Demizu, Y., Kurihara, M., Irie, K., Iwai, M., Asada, E., Kato, Y., and Maruyama, T., Bioorg. Med. Chem., 2013, vol. 21, p. 5900. https://doi.org/10.1016/j.bmc.2013.06.061

    Article  CAS  PubMed  Google Scholar 

  18. Tang, J., Maddali, K., Dries, C.D., Sham, Y.Y., Vince, R., Pommier, Y., and Wang, Zh., Bioorg. Med. Chem. Lett., 2011, vol. 21, p. 2400. https://doi.org/10.1016/j.bmcl.2011.02.069

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Rana, K., Kaur, B., and Kumar, B., Ind. J. Chem. (B), 2004, vol. 43, p. 1553.

    Google Scholar 

  20. Kumar, B., Kaur, B., Kaur, J., Parmar, A., Anand, R.D., and Kumar, H., Ind. J. Chem. (B), 2002, vol. 41, p. 1526.

    Google Scholar 

  21. Virsodia, V., Pissurlenkar, R.R.S., Manvar, D., Dholakia, Ch., Adlakha, P., Shah, A., and Coutinhio, E.C., Eur. J. Med. Chem., 2008, vol. 43, p. 2103. https://doi.org/10.1016/j.ejmech.2007.08.004

    Article  CAS  PubMed  Google Scholar 

  22. Srivastav, N.C., Rai, D., Tse, C., Agrawal, B., Kunimoto, D.Y., and Kumar, R., J. Med. Chem., 2010, vol. 53, p. 6180. https://doi.org/10.1021/jm100568q

    Article  CAS  PubMed  Google Scholar 

  23. Agarwal, A., Srivastava, K., Puri, S.K., and Chauhan, P.M.S., Bioorg. Med. Chem., 2005, vol. 13, p. 4645. https://doi.org/10.1016/j.bmc.2005.04.061

    Article  CAS  PubMed  Google Scholar 

  24. Singh, K., Kaur, H., Chibale, K., and Balzarini, J., Eur. J. Med. Chem., 2013, vol. 66, p. 314. https://doi.org/10.1016/j.ejmech.2013.05.046

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Rasheeda, K., Alva, V.D.P., Krishnaprasad, P.A., and Samshuddin, S., Int. J. Corros. Scale Inhib., 2018, vol. 7, p. 48. https://doi.org/10.17675/2305-6894-2018-7-1-5

    Article  CAS  Google Scholar 

  26. Classified Lists of Pesticides. http://www.alanwood.net/pesticides/class_pesticides.html.

  27. Grigoryan, A.A., Vestn. RAU. Ser. Fiz.-Mat. Estestv. Nauk, 2014, no. 2, p. 46.

    Google Scholar 

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Authors and Affiliations

  1. Research Center for Pesticide Synthesis and Plant Protection, National Agrarian University of Armenia, 0009, Yerevan, Armenia

    E. N. Hambardzumyan, A. S. Vorskanyan, L. V. Shahbazyan & A. P. Yengoyan

  2. Russian-Armenian University, 0051, Yerevan, Armenia

    A. P. Yengoyan

Authors
  1. E. N. Hambardzumyan
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  2. A. S. Vorskanyan
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  3. L. V. Shahbazyan
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  4. A. P. Yengoyan
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Correspondence to A. P. Yengoyan.

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Hambardzumyan, E.N., Vorskanyan, A.S., Shahbazyan, L.V. et al. Synthesis and Plant Growth Stimulating Action of 2-Amino-6-methylpyrimidine-4(3H)-thione Derivatives. Russ J Gen Chem 90, 208–216 (2020). https://doi.org/10.1134/S1070363220020073

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  • DOI: https://doi.org/10.1134/S1070363220020073

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