Abstract
The reactions of chloroethynylphosphonates with 2-aminoquinoline and 1-aminoisoquinoline proceeded chemo- and regioselectively to form novel fused tricyclic compounds with pharmacophore groups, namely dialkyl-(imidazo[1,2-a]quinolin-2-yl)- and (imidazo[2,1-a]isoquinolin-2-yl)phosphonates in high yield.
References
Krylov, A.S., Kaskevich, K.I., Erkhitueva, E.B., Svintsitskaya, N.I., and Dogadina, A.V., Tetrahedron Lett., 2018, vol. 59, no. 49, p. 4326. https://doi.org/10.1016/j.tetlet.2018.10.052
Krylov, A.S., Petrosian, A.A., Piterskaya, Yu.L., Svintsitskaya, N.I, and Dogadina, A.V., Beilstein J. Org. Chem., 2019, no. 15, p. 1563. https://doi.org/10.3762/bjoc.15.159
Dumitrascu, F., Georges, F., Georgescu, G., and Caira, M.R., Adv. Heterocycl. Chem., 2019, vol. 129, p. 155. https://doi.org/10.1016/bs.aihch.2019.01.004
Diaz, G., Miranda, I., and Diaz, M., Quinolines, Isoquinolines, Angustureine, and Congeneric Alkaloids Occurrence, Chemistry, and Biological Activity, in Phytochemicals. Isolation, Characterisation and Role in Human Health, Rao, V., Ed., IntechOpen, 2015. https://doi.org/10.5772/59819
Funding
This work was financially supported by the Russian Foundation for Basic Research (grant no. 19-03-00365) as part of the basic part of the governmental task of the Ministry of Education and Science of the Russian Federation (no. 4.5554.2017/8.9) using the equipment of the Engineering Center of the St. Petersburg State Institute of Technology and Center for Collective Use “Chemical Analysis and Materials Research” of St. Petersburg State University.
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Russian Text © The Author(s), 2019, published in Zhurnal Obshchei Khimii, 2019, Vol. 89, No. 12, pp. 1961–1964.
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Krylov, A.S., Denisova, A.S., Erkhitueva, E.B. et al. Reactions of Chloroethynylphosphonates with 2-Aminoquinoline and 1-Aminoisoquinoline. Russ J Gen Chem 89, 2597–2600 (2019). https://doi.org/10.1134/S1070363219120417
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DOI: https://doi.org/10.1134/S1070363219120417