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Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Likned Thiazole-1,2-isoxazole Derivatives

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Abstract

A series of novel 1,2,3-triazole linked thiazole-1,2-isoxazole derivatives has been designed, synthesized and characterized by 1H and 13C NMR, and mass spectral analysis. The compounds have been tested for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer) by using the MTT method using etoposide as the reference. Most of the tested compounds demonstrate good to moderate activity against all cell lines. The compounds 14b, 14e, 14g, and 14h are characterized by inhibitory activity stronger than that of etoposide.

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Authors and Affiliations

  1. Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh, 522510, India

    T. Yakantham & R. Ramesh Raju

  2. Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, 533003, India

    R. Sreenivasulu

  3. Department of Chemistry, S V Arts and Science College, Giddalur, Andhra Pradesh, 523357, India

    G. Alluraiah

  4. Department of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, 600116, Tamil Nadu, India

    M. B. Tej

Authors
  1. T. Yakantham
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  2. R. Sreenivasulu
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  3. G. Alluraiah
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  5. R. Ramesh Raju
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Correspondence to R. Ramesh Raju.

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Yakantham, T., Sreenivasulu, R., Alluraiah, G. et al. Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Likned Thiazole-1,2-isoxazole Derivatives. Russ J Gen Chem 89, 2522–2527 (2019). https://doi.org/10.1134/S1070363219120314

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  • DOI: https://doi.org/10.1134/S1070363219120314

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