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Synthesis, Structure, and Biological Activity of 4-R-4-Oxo-2-[2-(phenylamino)benzoyl]hydrazinylidene-N-hetarylbutanamides

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Abstract

Decyclization of N′-[5-R-2-oxofuran-3(2H)-ylidene]-2-(phenylamino)benzohydrazides under the action of heterocyclic amines leads to the formation of N-hetaryl-4-R-4-oxo-2-[2-(phenylamino)benzoyl]hydrazinylidenebutanamides. Antinociceptive and anti-inflammatory activity of the obtained compounds was studied.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation, Perm, 614990, Russia

    I. A. Kizimova, N. M. Igidov, S. V. Chashchina & A. I. Siutkina

  2. Perm State National Research University, Perm, 614068, Russia

    M. V. Dmitriev, S. V. Chashchina & R. R. Makhmudov

  3. Federal Research Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russia

    R. R. Makhmudov

Authors
  1. I. A. Kizimova
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  2. N. M. Igidov
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  3. M. V. Dmitriev
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  4. S. V. Chashchina
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  5. R. R. Makhmudov
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  6. A. I. Siutkina
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Corresponding author

Correspondence to I. A. Kizimova.

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Compliance with Ethical Standards The studies are carried out in accordance with all applicable international, national and institutional guidelines for the care and use of animals.

Conflict of Interest No Conflict of Interest was declared by the authors

Additional information

Russian Text © The Author(s), 2019, published in Zhurnal Obshchei Khimii, 2019, Vol. 89, No. 12, pp. 1820–1828.

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Kizimova, I.A., Igidov, N.M., Dmitriev, M.V. et al. Synthesis, Structure, and Biological Activity of 4-R-4-Oxo-2-[2-(phenylamino)benzoyl]hydrazinylidene-N-hetarylbutanamides. Russ J Gen Chem 89, 2345–2352 (2019). https://doi.org/10.1134/S107036321912003X

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  • DOI: https://doi.org/10.1134/S107036321912003X

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