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Synthesis of Macrocyclic Ttipeptidopyridine Schiff Base Candidates

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Abstract

In the current study, a series of macrocyclic tripeptide Schiff bases 2–6 were synthesized by using macrocyclic tripeptide hydrazide 1 as starting material. Treatment of hydrazide 1 with active carbonyl cycloalkanones gave cycloalkanone hydrazines 2a–2d. Also, condensation of 1 with aromatic and heterocyclic aldehydes, or aromatic and heterocyclic acetyl derivatives afforded the corresponding Schiff base candidates 3a–3e, 4a–4c, 5a–5c, and 6a–6c, respectively.

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Funding

Authors are grateful to King Saud University for funding the work through Researchers Supporting Project (project no. RSP-2019/66).

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Authors and Affiliations

  1. Synthetic Organic Lab, Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt

    H. A. Sallam

  2. Department of Photochemistry, National Research Center, Dokki, Cairo, 12622, Egypt

    R. E. Abdel-Mageid

  3. Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration and Development Chair (DEDC), King Saud University, Riyadh, 11451, Saudi Arabia

    A. E. Amr

  4. Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, 12622, Egypt

    A. E. Amr

Authors
  1. H. A. Sallam
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  2. R. E. Abdel-Mageid
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  3. A. E. Amr
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Corresponding author

Correspondence to A. E. Amr.

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Conflict of Interest

No conflict of interest was declared by the authors.

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Sallam, H.A., Abdel-Mageid, R.E. & Amr, A.E. Synthesis of Macrocyclic Ttipeptidopyridine Schiff Base Candidates. Russ J Gen Chem 89, 2308–2313 (2019). https://doi.org/10.1134/S1070363219110239

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  • DOI: https://doi.org/10.1134/S1070363219110239

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