Skip to main content
SpringerLink
Log in

Synthesis and Biological Activity of N-Aryl(alkyl)-2-[2-(9H-fluoren-9-ylidene)hydrazinylidene]-5,5-dimethyl-4-oxohexanamides

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

Ring opening of 5-tert-butyl-3-[(9H-fluoren-9-ylidene)hydrazinylidene]furan-2(3H)-one by the action of primary amines afforded a series of new 2-[(9H-fluoren-9-ylidene)hydrazinylidene]-5,5-dimethyl-4-oxohexan-amides. The synthesized compounds were tested for antinociceptive and antimicrobial activities.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Shipilovskikh, S.A., Rubtsov, A.E., Makhmudov, R.R., and Zalesov, V.V., RU Patent no. 2 389 724, 2008; Byull. Izobret., 2010, no. 14.

  2. Shipilovskikh, S.A., Makhmudov, R.R., Lupach, D.Yu., Pavlov, P.T., Babushkina, E.V., and Rubtsov, A.E., Pharm. Chem. J., 2013, vol. 47, no. 7, p. 366. doi https://doi.org/10.1007/s11094-013-0960-z

    Article  CAS  Google Scholar 

  3. Bykov, R.A., Trapeznikova, N.N., Balandina, S.Yu., Komarova, O.A., Makhmudov, R.R., Pulina, N.A., Sobin, F.V., and Rubtsov, A.E., Pharm. Chem. J., 2018, vol. 52, no. 5, p. 415. doi https://doi.org/10.1007/s11094-018-1833-2

    Article  CAS  Google Scholar 

  4. Pulina, N.A., Kozhukhar, V.Y., Kuznetsov, A.S., Starkova, A.V., and Rubtsov, A.E., Russ. Chem. Bull., Int. Ed., 2017, vol. 66, no. 8, p. 1497. doi https://doi.org/10.1007/s11172-017-1914-5

    Article  CAS  Google Scholar 

  5. Igidov, N.M., Makhmudov, R.R., and Fedorovtseva, A.N., RU Patent no. 2347072, 2007; Byull. Izobret., 2009, no. 3.

  6. Komarova, O.A., Igidov, N.M., Rubtsov, A.E., Zalesov, V.V., Makarov, A.S., and Toksarova, Yu.S., Russ. J. Org. Chem., 2010, vol. 46, no. 2, p. 236. doi https://doi.org/10.1134/S1070428010020156

    Article  CAS  Google Scholar 

  7. Tyuneva, A.V., Igidov, N.M., Koryagina, N.N., Borodin, A. Yu., Zakhmatov, A.V., Makarov, A.S., Toksarova, Yu.S., and Rubtsov, A.E., Russ. J. Org. Chem., 2011, vol. 47, no. 2, p. 258. doi https://doi.org/10.1134/S1070428011020163

    Article  CAS  Google Scholar 

  8. Pulina, N.A., Kuznetsov, A.S., and Rubtsov, A.E., Russ. J. Org. Chem., 2015, vol. 51, no. 7, p. 967. doi https://doi.org/10.1134/S1070428015070131

    Article  CAS  Google Scholar 

  9. Shipilovskikh, S.A. and Rubtsov, A.E., Russ. J. Org. Chem., 2014, vol. 50, no. 2, p. 298. doi https://doi.org/10.1134/S1070428014020286

    Article  CAS  Google Scholar 

  10. Shipilovskikh, S.A. and Rubtsov, A.E., Russ. Chem. Bull., Int. Ed., 2014, vol. 63, no. 9, p. 2205. doi https://doi.org/10.1007/s11172-014-0722-4

    Article  CAS  Google Scholar 

  11. Kuznetsov, A.S., Pulina, N.A., and Rubtsov, A.E., Abstracts of Papers, Mezhdunarodnyi kongress Kost-2015 (Int. Congr. Kost-2015), Moscow, 2015, p. 456.

  12. CrysAlisPro. Version 1.171.37.33 (release 27-03-2014 CrysAlis171.NET), Agilent Technologies.

  13. Sheldrick, G.M., Acta Crystallogr., Sect. A, 2008, vol. 64, no. 1, p. 112. doi https://doi.org/10.1107/S0108767307043930

    Article  CAS  PubMed  Google Scholar 

  14. Sheldrick, G.M., Acta Crystallogr., Sect. C., 2015, vol. 71, no. 1, p. 3. doi https://doi.org/10.1107/S2053229614024218

    Article  CAS  Google Scholar 

  15. Dolomanov, O.V., Bourhis, L.J., Gildea, R.J, and Howard, J.A.K., and Puschmann, H.J., Appl. Crystallogr., 2009, vol. 42, p. 339. doi https://doi.org/10.1107/S0021889808042726

    Article  CAS  Google Scholar 

  16. Komarova, O.A., Igidov, N.M., Koryagina N.N., Makarov A.S., Toksarova, Yu.S., and Rubtsov, A.E., Russ. J. Org. Chem, 2011, vol. 47, no. 1, p. 109. doi https://doi.org/10.1134/S1070428011010131

    Article  CAS  Google Scholar 

  17. Eddy, N.B. and Leimbach, D.J., J. Pharmacol. Exp. Ther., 1953, vol. 107, no. 3, p. 385.

    CAS  PubMed  Google Scholar 

  18. Mironov, A.N., Rukovodstvo po provedeniyu doklinicheskikh issledovanii lekarstvennykh veshchestv, (A Guide to Preclinical Trials of Drugs), Moscow: Grif i K 2012, part 1, p. 509.

    Google Scholar 

  19. Belen’kii, M.L., Elementy kolichestvennoi otsenki farmakologicheskogo effekta, (Elements of Quantitative Estimation of Pharmacological Effect), Leningrad: Medgiz 1963.

    Google Scholar 

  20. Novikova, VV. and Russkikh, A.A., Razrab. Regist. Lek. Sredstv, 2018, no. 2 (23), p. 32.

Download references

Author information

Authors and Affiliations

  1. Ministry of Health Protection of the Russian Federation, Perm State Pharmaceutical Academy, Perm, Russia

    A. I. Siutkina, N. M. Igidov & V. V. Novikova

  2. Perm State National Research University, Perm, Russia

    M. V. Dmitriev & R. R. Makhmudov

  3. Federal Research Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia

    R. R. Makhmudov

Authors
  1. A. I. Siutkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. M. Igidov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. V. Dmitriev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. R. Makhmudov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. V. Novikova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. I. Siutkina.

Additional information

Russian Text © The Author(s), 2019, published in Zhurnal Obshchei Khimii, 2019, Vol. 89, No. 7, pp. 1026–1032.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Siutkina, A.I., Igidov, N.M., Dmitriev, M.V. et al. Synthesis and Biological Activity of N-Aryl(alkyl)-2-[2-(9H-fluoren-9-ylidene)hydrazinylidene]-5,5-dimethyl-4-oxohexanamides. Russ J Gen Chem 89, 1388–1393 (2019). https://doi.org/10.1134/S1070363219070065

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363219070065

Keywords

Search

Navigation