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Synthesis and Biological Activity of N-Aryl(alkyl)-2-[2-(9H-fluoren-9-ylidene)hydrazinylidene]-5,5-dimethyl-4-oxohexanamides

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Abstract

Ring opening of 5-tert-butyl-3-[(9H-fluoren-9-ylidene)hydrazinylidene]furan-2(3H)-one by the action of primary amines afforded a series of new 2-[(9H-fluoren-9-ylidene)hydrazinylidene]-5,5-dimethyl-4-oxohexan-amides. The synthesized compounds were tested for antinociceptive and antimicrobial activities.

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Authors and Affiliations

  1. Ministry of Health Protection of the Russian Federation, Perm State Pharmaceutical Academy, Perm, Russia

    A. I. Siutkina, N. M. Igidov & V. V. Novikova

  2. Perm State National Research University, Perm, Russia

    M. V. Dmitriev & R. R. Makhmudov

  3. Federal Research Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia

    R. R. Makhmudov

Authors
  1. A. I. Siutkina
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  2. N. M. Igidov
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  3. M. V. Dmitriev
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  4. R. R. Makhmudov
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  5. V. V. Novikova
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Corresponding author

Correspondence to A. I. Siutkina.

Additional information

Russian Text © The Author(s), 2019, published in Zhurnal Obshchei Khimii, 2019, Vol. 89, No. 7, pp. 1026–1032.

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Siutkina, A.I., Igidov, N.M., Dmitriev, M.V. et al. Synthesis and Biological Activity of N-Aryl(alkyl)-2-[2-(9H-fluoren-9-ylidene)hydrazinylidene]-5,5-dimethyl-4-oxohexanamides. Russ J Gen Chem 89, 1388–1393 (2019). https://doi.org/10.1134/S1070363219070065

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