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Synthesis and Anticancer Evaluation of 2-{4-[5-(5-Substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl]-phenyl}thiazolo[4,5-b]pyridine Derivatives

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Abstract

In the present study a new series of 2-{4-[5-(5-substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl] phenyl}thiazolo[4,5-b]pyridine derivatives (11a–11j) are synthesized and tested for their anticancer activity against four human cancer cell lines including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian) by the MTT assay. Among synthesized compounds, 11b, 11c, 11d, 11g, and 11j exhibit activity higher than the standard drug.

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Acknowledgments

The authors would like to thank the management of the AMRI Hyderabad research Centre for giving an opportunity to carry out this research. The authors are also thankful to Mr. Ch. Ravi Kumar for providing synthesis facility.

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Authors and Affiliations

  1. Department of Chemistry, Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, Guntur, 522502, India

    Ch. P. Koteswara Rao, T. B. Rao, G. Kali Charan, B. Srinu & S. R. Maturi

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  1. Ch. P. Koteswara Rao
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  2. T. B. Rao
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  3. G. Kali Charan
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Correspondence to T. B. Rao.

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Koteswara Rao, C.P., Rao, T.B., Charan, G.K. et al. Synthesis and Anticancer Evaluation of 2-{4-[5-(5-Substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl]-phenyl}thiazolo[4,5-b]pyridine Derivatives. Russ J Gen Chem 89, 1023–1028 (2019). https://doi.org/10.1134/S1070363219050244

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  • DOI: https://doi.org/10.1134/S1070363219050244

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