Skip to main content
SpringerLink
Log in

Synthesis and Antibacterial Acivity of Some Novel Pyrimidine-Based Heterocycles

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

Cyclization of 1,2-diamino-4(4-chlorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 2 with a variety of electrophilic reagents results in formation of a new series of pyrimidine heterocycles including pyrimidotriazepines, pyrimidotriazines and triazolopyrimidines. Some newly synthesized compounds are tested for their antibacterial activity against Gram-positive and Gram-negative bacteria.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Khalifa, N.M, Nossier, E.S., Al-Omar, M.A. and Amr, A.E., Russ. J. Gen. Chem., 2016, vol. 86, p. 1948. doi https://doi.org/10.1134/S1070363216080284

    Article  CAS  Google Scholar 

  2. Mohamed, M.S, Awad, S.M. and Sayed, A.I., Molecules, 2010, vol. 15, p. 1882. doi https://doi.org/10.3390/molecules15031882.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Saikia, L., Das, B., Bharali, P. and Thakur, A.J., Tetrahedron Lett., 2014, vol. 55, p. 1796. doi https://doi.org/10.1016/j.tetlet.2014.01.128

    Article  CAS  Google Scholar 

  4. Acosta, P., Insuasty, B., Ortiz, A., Abonia, R., Sortino, M., Zacchino, S.A. and Quiroga, J., Arab. J. Chem., 2016, vol. 9, p. 481. doi https://doi.org/10.1016/j.arabjc.2015.03.002

    Article  CAS  Google Scholar 

  5. Sun, L., Wu, J., Zhang, L., Luo, M. and Sun, D., Molecules, 2011, vol. 16, p. 5618. doi https://doi.org/10.3390/molecules16075618

    Article  CAS  PubMed Central  Google Scholar 

  6. Hanna, M.M., Eur. J. Med. Chem., 2012, vol. 55, p. 12. doi https://doi.org/10.1016/j.ejmech.2012.06.048

    Article  CAS  PubMed  Google Scholar 

  7. Wang, S., Deng, X., Zheng, Y., Yuan, Y., Quan, Z. and Guan, L., Eur. J. Med. Chem., 2012, vol. 56, p. 139. doi https://doi.org/10.1016/j.ejmech.2012.08.027

    Article  CAS  PubMed  Google Scholar 

  8. Rahaman, S.A., Pasad, Y.R., Kumar, P. and Kumar, B., Saudi Pharm. J., 2009, vol. 17, p. 255. doi https://doi.org/10.1016/jjsps.2009.08.001

    Article  PubMed  PubMed Central  Google Scholar 

  9. Lee, H.W., Kim, B.Y., Ahn, J.B., Kang, S.K., Lee, J.H., Shin, J.S., Ahn, S.K., Lee, S.J. and Yoon, S.S., Eur. J. Med. Chem, 2005, vol. 40, p. 862. doi https://doi.org/10.1016/j.ejmech.2005.03.019

    Article  CAS  PubMed  Google Scholar 

  10. Mohamed, M.S., Kamel, R. and Fatahala, S.S., Eur. J. Med. Chem, 2010, vol. 45, p. 2994. doi https://doi.org/10.1016/j.ejmech.2010.03.028

    Article  CAS  PubMed  Google Scholar 

  11. Wang, Y., Xu, F., Zhu, Y., Song, B., Luo, D., Yu, G., Chen, S., Xue, W. and Wu., J., Bioorg. Med. Chem. Lett, 2018, vol. 28, p. 2979. doi https://doi.org/10.1016/j.bmcl.2018.06.049

    Article  CAS  PubMed  Google Scholar 

  12. Abu-Hashem, A.A., Youssef, M.M. and Hussein, H.A.R., J. Chin. Chem. Soc., 2011, vol. 58, p. 41. doi https://doi.org/10.1002/jccs.201190056

    Article  CAS  Google Scholar 

  13. Gaber, A.A., Bayoumi, A.H., El-morsy, A.M., Sherbiny, F.F., Mehany, A.B.M. and Eissa, I.H., Bioorg. Chem, 2018, vol. 80, p. 375. doi https://doi.org/10.1016/j.bioorg.2018.06.017

    Article  CAS  PubMed  Google Scholar 

  14. El-Sayed, H.A, Abdel Hamid, A.M, Assy, M.G. and Farag, T.S., Synth. Commun., 2018, vol. 48, p. 794. doi https://doi.org/10.1080/00397911.2017.1422522

    Google Scholar 

  15. Abdel Hamid, A.M. and Shehta, W., J. Iran. Chem. Soc, 2018, vol. 15, p. 2771. doi https://doi.org/10.1007/s13738-018-1464-2

    Article  CAS  Google Scholar 

  16. Abdelghani, E., Said, S.A., Assy, M.G. and Abdel Hamid, A.M., Arab. J. Chem., 2017, vol. 10, p. S2926. doi https://doi.org/10.1016/j.arabjc.2013.11.025

    Article  CAS  Google Scholar 

  17. Bonev, B., Hooper, J. and Parisot, J., J. Antimicrob. Chemoth., 2008, vol. 61, p. 1301. doi https://doi.org/10.1093/jac/dkn090

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

    W. Shehta & A. M. Abdel Hamid

Authors
  1. W. Shehta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. M. Abdel Hamid
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. M. Abdel Hamid.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shehta, W., Abdel Hamid, A.M. Synthesis and Antibacterial Acivity of Some Novel Pyrimidine-Based Heterocycles. Russ J Gen Chem 89, 806–812 (2019). https://doi.org/10.1134/S1070363219040273

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363219040273

Keywords

Search

Navigation