Alkyl 3-Bromo-3-nitroacrylates in Reactions with Aliphatic Alcohols


The reactions of alkyl 3-bromo-3-nitroacrylates with aliphatic alcohols at reflux led to the formation of O-adducts—alkyl 2-alkoxy-3-bromo-3-nitropropanoates isolated as mixtures of diastereomers; their structure was proved using 1H, 13C-{1H} NMR, and IR spectroscopy methods.

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Makarenko, S.V., Pelipko, V.V., Pavchenko, M.M. et al. Alkyl 3-Bromo-3-nitroacrylates in Reactions with Aliphatic Alcohols. Russ J Gen Chem 89, 532–535 (2019).

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  • nitroacrylates
  • alcohols
  • nucleophilic addition
  • diastereomers
  • diastereotopy