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Synthesis and Anticancer Activity of Amide Derivatives of 1,2-Isoxazole Combined 1,2,4-Thiadiazole

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Abstract

A series of amide derivatives of 1,2-isoxazole combined with 1,2,4-thiadiazole are synthesized 11a–11j. Their chemical structures are confirmed by 1H and 13C NMR, and mass spectra. The products are tested for their anticancer activity against four types of human cancer cell lines, including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian). Etoposide is used as a positive control. Most of the compounds show good anticancer activity. The compounds 11b, 11c, 11d, 11e, 11g, and 11j demonstrate more potent activity than etoposide.

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Authors and Affiliations

  1. Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, 521001, India

    S. Shahinshavali & M. V. B. Rao

  2. Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, 533003, India

    R. Sreenivasulu

  3. Department of Chemistry, SRR and CVR Government Degree College (Autonomous), Vijayawad, Andhra Pradesh, 520004, India

    V. R. Guttikonda

  4. Department of Chemistry, Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, Andhra Pradesh, 522502, India

    D. Kolli

Authors
  1. S. Shahinshavali
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  2. R. Sreenivasulu
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  3. V. R. Guttikonda
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  4. D. Kolli
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  5. M. V. B. Rao
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Correspondence to M. V. B. Rao.

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Shahinshavali, S., Sreenivasulu, R., Guttikonda, V.R. et al. Synthesis and Anticancer Activity of Amide Derivatives of 1,2-Isoxazole Combined 1,2,4-Thiadiazole. Russ J Gen Chem 89, 324–329 (2019). https://doi.org/10.1134/S1070363219020257

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  • DOI: https://doi.org/10.1134/S1070363219020257

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