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Russian Journal of General Chemistry

, Volume 89, Issue 1, pp 8–13 | Cite as

Synthesis and Structure of Biologically Active 1,2-Bis(2-oxocycloalkyl)ethane-1,2-diones and 3,4-Dioxo-4-(2-oxocycloalkyl)butanoic Acid Esters

  • P. P. MukovozEmail author
  • E. S. Dankovtseva
  • V. P. Mukovoz
  • V. V. Abramova
  • D. S. Korol’kova
  • A. N. Sizentsov
  • E. A. Danilova
Article
  • 9 Downloads

Abstract

A two-step procedure has been proposed for the synthesis of 1,2-bis(2-oxocycloalkyl)ethane-1,2-diones and 3,4-dioxo-4-(2-oxocycloalkyl)butanoic acid esters by condensation of cycloalkyl ketones with dimethyl oxalate or of alkyl acetates with dialkyl oxalates and cycloalkyl ketones, respectively. The structure of the synthesized compounds has been discussed on the basis of their IR, 1H NMR, and mass spectra, and their antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Salmonella typhimurium strains has been estimated.

Keywords

1,3,4,6-tetracarbonyl compounds cycloalkyl ketones 1,2-bis(2-oxocycloalkyl)ethane-1,2-diones 3,4-dioxo-4-(2-oxocycloalkyl)butanoic acid esters 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • P. P. Mukovoz
    • 1
    Email author
  • E. S. Dankovtseva
    • 1
  • V. P. Mukovoz
    • 1
  • V. V. Abramova
    • 1
  • D. S. Korol’kova
    • 2
  • A. N. Sizentsov
    • 2
  • E. A. Danilova
    • 3
  1. 1.All-Russian Research Institute of PhytopathologyBol’shie Vyazemy, Moscow oblastRussia
  2. 2.Orenburg State UniversityOrenburgRussia
  3. 3.Ivanovo State University of Chemistry and TechnologyIvanovoRussia

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