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Synthesis and Antibacterial Evaluation of Benzofuran Based 3,5-Disubstituted Isoxazoles

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Abstract

A series of novel benzofuran-isoxazole 7a–7j hybrid heterocyclic molecules are synthesized. The structures of compounds 7a–7j are assessed by IR, NMR, MASS spectroscopy and elemental analysis. The target compounds 7a–7j are screened for their antibacterial activity and demonstrated excellent to moderate activity against gram-positive and gram-negative bacteria.

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References

  1. Nasef, A., El-Naem, S. and El Shabrawy, O., Egyptian J. Pharm. Sci. 1992, vol. 33, p. 463.

    CAS  Google Scholar 

  2. Powers, L.J., J. Med. Chem., 1976, vol. 19, no. 1, p. 57. doi https://doi.org/10.1021/jm00223a013

    Article  CAS  PubMed  Google Scholar 

  3. Nagahara, T., Yokoyama, Y., Inamura, K., Katakura, S.-I., Komoriya, S., Yamaguchi, H., Hara, T., and Iwamoto, M., J. Med. Chem., 1994, vol. 37, no. 8, p. 1200. doi https://doi.org/10.1021/jm00034a018

    Article  CAS  PubMed  Google Scholar 

  4. Gubin, J., de Vogelaer, H., Inion, H., Houben, C., Lucchetti, J., Mahaux, J., Rosseels, G., Peiren, M., and Clinet, M., J. Med. Chem., 1993, vol. 36, no. 10, p. 1425. doi https://doi.org/10.1021/jm00062a015

    Article  CAS  PubMed  Google Scholar 

  5. Manna, K. and Agrawal, Y.K., Bioorg. Med. Chem. Lett. 2009, vol. 19, no. 10, p. 2688. doi https://doi.org/10.1016/j.bmcl.2009.03.161

    Article  CAS  PubMed  Google Scholar 

  6. Gündoğdu-Karaburun, N., Benkli, K., Tunali, Y., Uçucu, Ü., and Demirayak, Ş., Eur. J. Med. Chem. 2006, vol. 41, no. 5, p. 651. doi https://doi.org/10.1016/j.ejmech.2005.12.013

    Article  CAS  Google Scholar 

  7. Chakrabarti, J.K., Eggleton, R.J., Gallagher, P.T., Harvey, J., Hicks, T.A., Kitchen, E.A., and Smith, C.W., J. Med. Chem., 1987, vol. 30, no. 9, p. 1663. doi https://doi.org/10.1021/jm00392a024

    Article  CAS  PubMed  Google Scholar 

  8. Yong, D., Yum, J.H., Lee, K., Chong, Y., Choi, S.H., and Rhee, J.K., Antimicrob. Agents Chemother. 2004, vol. 48, no. 1, p. 352. doi https://doi.org/10.1128/AAC.48.1.352-357.2004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Gennaro, M., Giacosa, D., Gioannini, E., and Angelino, S., J. Liq. Chromatogr. Rel. Technol., 1997, vol. 20, no. 3, p. 413.

    Article  CAS  Google Scholar 

  10. Schwarcz, R., Hökfelt, T., Fuxe, K., Jonsson, G., Goldstein, M., and Terenius, L., Exp. Brain Res. 1979, vol. 37, no. 2, p. 199.

    Article  CAS  PubMed  Google Scholar 

  11. Tsunoda, K., Inoue, N., Aoyagi, Y., and Sugahara, T., J. Food Hyg. Soc. Jpn., 1993, vol. 34, no. 1, p. 12.

    Article  CAS  Google Scholar 

  12. Olpe, H.-R. and Koella, W., Experientia 1978, vol. 34, no. 2, p. 235.

    Article  CAS  PubMed  Google Scholar 

  13. Sunitha, V., Kumar, A.K., Shankar, B., Kumar, A.A., Krishna, T., Lincoln, C.A., and Pochampalli, J., Russ. J. Gen. Chem. 2017, vol. 87, no. 2, p. 322. doi https://doi.org/10.1134/S1070363217020281

    Article  CAS  Google Scholar 

  14. Bauer, A., Am. J. Clin. Pathol. 1966, vol. 45, p. 493. doi https://doi.org/10.1093/ajcp/45.4_ts.493

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, University College of Science, Osmania University, Saifabad, Hyderabad, Telangana, 500004, India

    V. Sunitha & V. Gopal Reddy

  2. Department of Humanities and Sciences, Vardhaman College of Engineering, Shamshabad, Hyderabad, Telangana, 501218, India

    A. Kishore Kumar

  3. Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, 500007, India

    Ch. Abraham Lincoln & P. Jalapathi

Authors
  1. V. Sunitha
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  2. A. Kishore Kumar
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  3. Ch. Abraham Lincoln
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  4. P. Jalapathi
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  5. V. Gopal Reddy
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Correspondence to P. Jalapathi.

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Sunitha, V., Kumar, A.K., Lincoln, C.A. et al. Synthesis and Antibacterial Evaluation of Benzofuran Based 3,5-Disubstituted Isoxazoles. Russ J Gen Chem 88, 2669–2674 (2018). https://doi.org/10.1134/S1070363218120319

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  • DOI: https://doi.org/10.1134/S1070363218120319

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