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Phosphorylation of Betti Base with Bis(diethylamino)phosphoryl Chloride

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Abstract

The reaction of bis(diethylamino)phosphoryl chloride with N-Boc-protected 1-(α-aminobenzyl)-2- naphthol (Betti base) proceeded via O-phosphorylation of the phenolic OH group to form the target product as trifluoroacetate salt. The latter reacted with O,O-diethyl thiophosphorylisothiocyanate to give thiourea bearing a chiral Betti base fragment.

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Authors and Affiliations

  1. A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088, Russia

    K. E. Metlushka, D. N. Sadkova, K. A. Nikitina, Z. R. Yamaleeva, K. A. Ivshin, O. N. Kataeva & V. A. Alfonsov

  2. Butlerov Chemical Institute, Kazan (Volga Region) Federal University, Kazan, Tatarstan, Russia

    K. A. Ivshin

Authors
  1. K. E. Metlushka
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  2. D. N. Sadkova
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  3. K. A. Nikitina
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  4. Z. R. Yamaleeva
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  5. K. A. Ivshin
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  6. O. N. Kataeva
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  7. V. A. Alfonsov
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Corresponding author

Correspondence to V. A. Alfonsov.

Additional information

Dedicated to the 115th anniversary of B.A. Arbuzov’s birth

Original Russian Text © K.E. Metlushka, D.N. Sadkova, K.A. Nikitina, Z.R. Yamaleeva, K.A. Ivshin, O.N. Kataeva, V.A. Alfonsov, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 11, pp. 1931–1934.

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Metlushka, K.E., Sadkova, D.N., Nikitina, K.A. et al. Phosphorylation of Betti Base with Bis(diethylamino)phosphoryl Chloride. Russ J Gen Chem 88, 2453–2456 (2018). https://doi.org/10.1134/S1070363218110348

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  • DOI: https://doi.org/10.1134/S1070363218110348

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