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Synthesis of Hybrid Pharmacophores Based on Adducts of N-Sulfinylaniline and Norbornadiene

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Abstract

Acylation of benzothiazinesulfonamides obtained by the oxidation of N-sulfinylaniline and norbornadiene adducts with acid chlorides and carboxylic anhydrides led to the formation of N-acylated sulfonamide hybrid pharmacophores. Molecular and crystal structure of the acylated products was established by X-ray diffraction method.

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Authors and Affiliations

  1. Kant Baltic Federal University, Kaliningrad, Russia

    O. A. Tevs & Ya. V. Veremeychik

  2. A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088, Russia

    O. A. Lodochnikova & I. A. Litvinov

  3. Butlerov Institute of Chemistry, Kazan Federal (Volga Region) University, Kazan, Tatarstan, Russia

    O. A. Lodochnikova & V. V. Plemenkov

  4. Tupolev Kazan National Research Technical University (KAI), Kazan, Tatarstan, Russia

    I. A. Litvinov

Authors
  1. O. A. Tevs
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  2. Ya. V. Veremeychik
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  3. O. A. Lodochnikova
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  4. V. V. Plemenkov
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  5. I. A. Litvinov
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Corresponding author

Correspondence to O. A. Lodochnikova.

Additional information

Dedicated to the 115th anniversary of B.A. Arbuzov’s birth

Original Russian Text © O.A. Tevs, Ya.V. Veremeychik, O.A. Lodochnikova, V.V. Plemenkov, I.A. Litvinov, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 11, pp. 1915–1919.

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Tevs, O.A., Veremeychik, Y.V., Lodochnikova, O.A. et al. Synthesis of Hybrid Pharmacophores Based on Adducts of N-Sulfinylaniline and Norbornadiene. Russ J Gen Chem 88, 2438–2441 (2018). https://doi.org/10.1134/S1070363218110300

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  • DOI: https://doi.org/10.1134/S1070363218110300

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