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Synthesis and Cytotoxicity of 1,4-Naphthoquinone Oxime Derivatives

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Abstract

A series of hydroxylated 1,4-naphthoquinone oximes were designed and synthesized. The in vitro cytotoxicity of these compounds was evaluated against five human cancer cell lines and human skin fibroblast cell line. Among them, compounds (1E,4E)-6-{1-[(5-Hydroxypentyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8- dimethoxynaphthalene-1,4-dione dioxime and (1E,4E)-6-{1-[(6-Hydroxyhexyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8-dimethoxynaphthalene-1,4-dione dioxime displayed higher cytotoxicity in three cancer cell lines than the positive drug 5-fluorouracil

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Authors and Affiliations

  1. School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China

    Q. Zhang, J. Dong, Q. Meng, G. Huang & S. Li

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  1. Q. Zhang
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  2. J. Dong
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  3. Q. Meng
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  4. G. Huang
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  5. S. Li
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Correspondence to Q. Zhang.

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The text was submitted by the authors in English.

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Zhang, Q., Dong, J., Meng, Q. et al. Synthesis and Cytotoxicity of 1,4-Naphthoquinone Oxime Derivatives. Russ J Gen Chem 88, 2388–2393 (2018). https://doi.org/10.1134/S1070363218110221

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  • DOI: https://doi.org/10.1134/S1070363218110221

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