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Synthesis of Amphiphilic Oligomers of Acrylic Acid

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Abstract

Synthesis of amphiphilic oligomers of acrylic acid via radical polymerization in the presence of thiols as molecular mass regulators is described. The effect of the length of the introduced hydrophobic terminal group on the critical micellization concentration of the acrylic acid oligomers has been elucidated. It has been shown that the incorporation of an antituberculous drug (prothionamide) in the micelles of acrylic acid oligomers is enhanced with the increase in the length of the hydrophobic moiety. The preparation of hydroxyapatite-filled calcium-polycarboxylate bone cements containing prothionamide (promising for the sealing of postoperative cavities) is described.

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Correspondence to Ya. O. Mezhuev.

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Original Russian Text © Ya.O. Mezhuev, O.Yu. Sizova, A.L. Luss, M.I. Shtilman, Yu.V. Korshak, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 10, pp. 1705–1710.

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Mezhuev, Y.O., Sizova, O.Y., Luss, A.L. et al. Synthesis of Amphiphilic Oligomers of Acrylic Acid. Russ J Gen Chem 88, 2144–2148 (2018). https://doi.org/10.1134/S1070363218100195

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  • DOI: https://doi.org/10.1134/S1070363218100195

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