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Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones

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Abstract

A series of bis-isoxazoles blended chalcones 7a–7j are synthesized in high yields. The combination of three pharmacologically active moieties in a single scaffold results in the synergistic effect in their bioactivity. All the newly synthesized compounds are characterized by IR, NMR and Mass spectroscopy. The target compounds 7a–7j are assessed for their antimicrobial activity and these demonstrate high to excellent activity against tested bacterial and fungal strains. The products 7f, 7h, 7j, and 7i demonstrate potent antimicrobial activity at concentrations 75 and 100 μg/mL.

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Authors and Affiliations

  1. Department of Chemistry, University College of Science, Osmania University, Saifabad, Hyderabad, Telangana, 500004, India

    V. Sunitha & P. Jalapathi

  2. Department of Humanities and Sciences, Vardhaman College of Engineering, Shamshabad, Hyderabad, Telangana, 501218, India

    A. Kishore Kumar & P. Shankaraiah

  3. Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, 500007, India

    M. Mahesh & Ch. Abraham Lincoln

Authors
  1. V. Sunitha
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  2. A. Kishore Kumar
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  3. M. Mahesh
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  4. P. Shankaraiah
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  5. P. Jalapathi
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  6. Ch. Abraham Lincoln
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Correspondence to V. Sunitha.

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Sunitha, V., Kumar, A.K., Mahesh, M. et al. Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones. Russ J Gen Chem 88, 1904–1911 (2018). https://doi.org/10.1134/S1070363218090232

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  • DOI: https://doi.org/10.1134/S1070363218090232

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