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Synthesis and Anti-HBV Activity of Novel Substituted Pyrimidine Glycosides and Their Acyclic Analogues

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Abstract

New aryl substituted uracil and thiouracil glycosides are synthesized by glycosylation at N1 in the pyrimidine nucleus using glycopyranosyl halides in basic medium. In addition C-linked hydrazinyl acyclic sugar derivatives exhibiting different sugar moieties, attached at C6, are also prepared. Antiviral activity of the newly synthesized compounds is studied against Hepatitis B virus (HBV). The antiviral tests data indicated high activity of compounds 6b, 6c and 12a–12c with mild cytotoxic effects. The influence of glycosyl moieties attached to the substituted pyrimidine system in addition to the substitution at the aryl fragment on activity is discussed.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, 32511, Egypt

    M. A. Hawata & Adel A.-H. Abdel-Rahman

  2. Photochemistry Department, National Research Centre, Dokki, Cairo, 12622, Egypt

    W. A. El-Sayed

Authors
  1. M. A. Hawata
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  2. W. A. El-Sayed
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  3. Adel A.-H. Abdel-Rahman
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Correspondence to W. A. El-Sayed.

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Hawata, M.A., El-Sayed, W.A. & Abdel-Rahman, A.AH. Synthesis and Anti-HBV Activity of Novel Substituted Pyrimidine Glycosides and Their Acyclic Analogues. Russ J Gen Chem 88, 1734–1744 (2018). https://doi.org/10.1134/S1070363218080285

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  • DOI: https://doi.org/10.1134/S1070363218080285

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