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Synthesis of New Tetrazole Derivatives and Their Biological Evaluation

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Abstract

An operationally simple and efficient method of synthesis of novel 1,5-disubstituted tetrazoles with high yields from easily accessible 2-(2-benzamido-3-arylacrylamido)acetate under mild conditions is developed. Anticancer and anti-microbial tests of the new tetrazole derivatives have been carried out.

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Authors and Affiliations

  1. Photochemistry Department, National Research Centre, Dokki, Cairo, 12622, Egypt

    H. A. Soliman

  2. Peptide Chemistry Department, National Research Centre, Dokki, Cairo, 12622, Egypt

    A. Kalmouch

  3. Tanning Materials and Leather Technology Department, National Research Centre, Dokki, Cairo, 12622, Egypt

    H. M. Awad

  4. Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, Cairo, 12622, Egypt

    N. A. M. Abdel Wahed

Authors
  1. H. A. Soliman
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  2. A. Kalmouch
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  3. H. M. Awad
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  4. N. A. M. Abdel Wahed
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Correspondence to H. A. Soliman.

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The text was submitted by the authors in English.

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Soliman, H.A., Kalmouch, A., Awad, H.M. et al. Synthesis of New Tetrazole Derivatives and Their Biological Evaluation. Russ J Gen Chem 88, 1726–1733 (2018). https://doi.org/10.1134/S1070363218080273

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  • DOI: https://doi.org/10.1134/S1070363218080273

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