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DNA Binding Studies and Evaluation of Electrochemical Parameters of New Tri-and Di-Organotin(IV) Complexes of 4-(1H-Indol-3-yl)butanoic Acid

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Abstract

New triorganotin(IV) [R3SnL where R = Me (1), Bu (2), Ph (3)] and diorganotin(IV) [R2SnL2, where R = Me (4), Bu (5), Ph (6)] derivatives of 4-(1H-indol-3-yl)butanoic acid (HL) were prepared and characterized by FT-IR and 1H and 13C NMR spectroscopy. Interaction between DNA and selected compounds was studied by UV-Vis spectroscopy and viscometry. The binding constants calculated on the basis of the accumulated data reveal the following order of binding strength: compound 2 > 1 > 5 > 4. Electrochemical parameters such as diffusion coefficient and charge transfer coefficient are evaluated with cyclic voltammetry. The results demonstrate that diorganotin(IV) complexes are characterized by higher diffusion coefficient than triorganotin(IV) analogues. In case of triorganotin(IV) complexes, the lower coordination number allows a solvent to interact with Sn(IV) center and hence decreases the rate of diffusion.

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Authors and Affiliations

  1. Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan

    S. Khalid & S. Ali

  2. Department of Chemistry, Faculty of Sciences, Allama Iqbal Open University Islamabad, Islamabad, 44000, Pakistan

    F. Shaheen

Authors
  1. S. Khalid
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  2. F. Shaheen
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  3. S. Ali
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Correspondence to F. Shaheen.

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The text was submitted by the authors in English.

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Khalid, S., Shaheen, F. & Ali, S. DNA Binding Studies and Evaluation of Electrochemical Parameters of New Tri-and Di-Organotin(IV) Complexes of 4-(1H-Indol-3-yl)butanoic Acid. Russ J Gen Chem 88, 1720–1725 (2018). https://doi.org/10.1134/S1070363218080261

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  • DOI: https://doi.org/10.1134/S1070363218080261

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