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Synthesis and Characterization of New Nano-Sized Selenium Compounds to Further Use as Antioxidants Drugs

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Abstract

Here we report the studies on selenium coordination compounds, in particular selenium nanoparticles (Nps), that can be used in pharmacology. The Se Nps were synthesized by three pathways and characterized by FT-IR, XRD, SEM, TEM, and EDX analyses. Сomplexes of Se(0) with alanine, tyrosine, serine, aspartic acid, histidine, and glycine as ligands, are synthesized in a 1: 2 molar ratio. IR spectra of solid complexes indicate that selenium metal is coordinated with the amino and carboxylate groups. The complexes are square planar structures with two amino acids bidentate ligands occupying the corners. Binary complexes of Se Nps with Ala, Tyr, Ser, Asp, His, and Gly react readily with vitamine B3 (nia) affording mixed ligand complexes of the types [Se(AA)2(nia)2], where AA indicates the above aminoacids. These complexes are determined to have a 1 : 2 : 2 (Se : AA : nia) stoichiometry with coordination number 6. The structures of products are studied by FT-IR, Raman and UV-Vis spectra, XRD, SEM/TEM, and TG/DTG. Conductance of the complexes in DMSO indicates their non-electrolytic nature. The complexes demonstrate antioxidant activity with potent scavenging property.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia

    F. A. Saad, N. M. El-Metwaly & A. M. Khedr

  2. Chemistry Department Faculty of Science, Mansoura University, Mansoura, Egypt

    N. M. El-Metwaly

  3. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt

    M. S. Refat

  4. Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Taif, 21974, Saudi Arabia

    M. S. Refat

  5. Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt

    A. M. Khedr

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  1. F. A. Saad
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  2. N. M. El-Metwaly
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  3. M. S. Refat
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Correspondence to M. S. Refat.

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Saad, F.A., El-Metwaly, N.M., Refat, M.S. et al. Synthesis and Characterization of New Nano-Sized Selenium Compounds to Further Use as Antioxidants Drugs. Russ J Gen Chem 88, 1258–1265 (2018). https://doi.org/10.1134/S107036321806035X

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