Synthesis and Antimicrobial Activity of 3-(1-Aryl-1H-1,2,3-triazol-4-yl)-2-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl)propan-1-ones
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A number of novel 3-(1-aryl-1H-1,2,3-triazol-4-yl)-2-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl) propan-1-ones has been synthesized from 2-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl)ethanone by its propargylation followed by the click reaction. Structures of all the newly synthesized compounds were characterized by 1H and 13C NMR, and Mass spectra. Their antimicrobial activity was evaluated.
Keywordsfluorinated organic molecule propargylation click reaction 1,2,3-triazole antimicrobial activity
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The authors are thankful to the Head, Department of Chemistry for providing laboratory facilities. The authors are also thankful to the Director, Central Facilities for Research and Development (CFRD), Osmania University for providing IR and NMR spectral analysis and also thankful to University College of Science, Saifabad, Osmania University.
- 8.Nagamani, M., Kishore Kumar, A., Sunitha, V., Jalapathi, P., Jayasree, D., and Shravan Kumar, G., Der Pharma Chemica, 2017, vol. 9(4), p. 36.Google Scholar