Russian Journal of General Chemistry

, Volume 88, Issue 4, pp 812–814 | Cite as

Synthesis and Antimicrobial Activity of 3-(1-Aryl-1H-1,2,3-triazol-4-yl)-2-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl)propan-1-ones

  • M. Nagamani
  • Ch. Anjaiah
  • D. Praveen
  • P. Jalapathi


A number of novel 3-(1-aryl-1H-1,2,3-triazol-4-yl)-2-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl) propan-1-ones has been synthesized from 2-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl)ethanone by its propargylation followed by the click reaction. Structures of all the newly synthesized compounds were characterized by 1H and 13C NMR, and Mass spectra. Their antimicrobial activity was evaluated.


fluorinated organic molecule propargylation click reaction 1,2,3-triazole antimicrobial activity 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.



The authors are thankful to the Head, Department of Chemistry for providing laboratory facilities. The authors are also thankful to the Director, Central Facilities for Research and Development (CFRD), Osmania University for providing IR and NMR spectral analysis and also thankful to University College of Science, Saifabad, Osmania University.


  1. 1.
    Pervaram, S., Ashok, D., Rao, B.A., Sarasija, M., and Reddy, C.V.R., Russ. J. Gen. Chem., 2017, vol. 87, p. 2454. doi 10.1134S1070363217100280CrossRefGoogle Scholar
  2. 2.
    Sowjanya, T., Jayaprakash Rao, Y., and Murthy, N.Y.S., Russ. J. Gen. Chem., 2017, vol. 87, p. 1864. doi 10.1134/S1070363217080357CrossRefGoogle Scholar
  3. 3.
    Guo, Y., Liu, C., Song, H., Wang, F.L., Zou, Y., Wu, Q.Y., and Hu, H.G., RSC Adv., 2017, vol. 7, p. 2110. doi 10.1039/C6RA26617GCrossRefGoogle Scholar
  4. 4.
    Silva, F.D.C.D., Souza, M.C.B.V.D., Frugulhetti, I.I.P., Castro, H.C., Souza, S.L.D.O., Souza, T.M.L.D., Rodrigues, D.Q., Souza, A.M.T., Abreu, P.A., Passamani, F., Rodrigues, C.R., and Ferreira, V.F., Eur. J. Med. Chem., 2009, vol. 44, p. 373. doi 10.1016/j.ejmech.2008.02.047CrossRefGoogle Scholar
  5. 5.
    Kouznetsov, V.V., Gomez, C.M.M., Derita, M.G., Svetaz, L., Olmo, E.D., and Zacchino, S.A., Bioorg. Med. Chem., 2012, vol. 20, p. 6506. doi 10.1016/j.bmc.2012.08.036CrossRefPubMedGoogle Scholar
  6. 6.
    Zhang, D.W., Zhang, Y.M., Li, J., Zhao, T.Q., Gu, Q., and Lin, F., Ultrason. Sonochem., 2017, vol. 36, p. 343. doi 10.1016/j.ultsonch.2016.12.011CrossRefPubMedGoogle Scholar
  7. 7.
    Gill, C., Jadhav, G., Shaikh, M., Kale, R., Ghawalkar, A., Nagargoje, D., and Shiradkar, M., Bioorg. Med. Chem. Lett., 2008, vol. 18, p. 6244. doi 10.1016/j.bmcl.2008.09.096CrossRefPubMedGoogle Scholar
  8. 8.
    Nagamani, M., Kishore Kumar, A., Sunitha, V., Jalapathi, P., Jayasree, D., and Shravan Kumar, G., Der Pharma Chemica, 2017, vol. 9(4), p. 36.Google Scholar
  9. 9.
    Kishore Kumar, A., Sunitha, V., Shankar, B., Krishna, T.M., Lincoln, Ch.A., and Jalapathi, P., Russ. J. Gen. Chem., 2017, vol. 87, p. 2011. doi 10.1134/S1070363217090171CrossRefGoogle Scholar
  10. 10.
    Sunitha, V., Kishore Kumar, A., Shankar, B., Anil Kumar, A., Krishna, T.M., Lincoln, Ch.A., and Jalapathi, P., Russ. J. Gen. Chem., 2017, vol. 87, p. 322. doi 10.1134/S1070363217020281CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • M. Nagamani
    • 1
  • Ch. Anjaiah
    • 2
  • D. Praveen
    • 1
  • P. Jalapathi
    • 1
  1. 1.Department of Chemistry, University College of Science, SaifabadOsmania UniversityHyderabad, TelanganaIndia
  2. 2.Department of Chemistry, University College of ScienceOsmania UniversityHyderabad, TelanganaIndia

Personalised recommendations