Russian Journal of General Chemistry

, Volume 88, Issue 4, pp 774–779 | Cite as

Synthesis, Antimicrobial Activity, and Docking Studies of 2-Mercapto Substituted Quinazolin-4(3H)-one and Their Derivatives

  • P. Balaswamy
  • S. Aravind
  • S. Purushotham Reddy
  • B. Satyanarayana


An efficient, eco-friendly synthesis of a series of 2-{[3-oxo-3-(alkyl/aryl-1-yl)alkyl]thio}-3-substituted quinazolin-4(3H)-ones employing quinazolin-4(3H)-one and corresponding halo-acyl/haloalkyl as electrophiles is presented. The products were assayed for anti-bacterial activity on four bacterial species (Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, and Staphylococcus aureus). In-silico molecular docking studies were carried out.


quinazolin-4(3H)-one derivatives antibacterial activity molecular docking 


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The author Balaswamy Puligilla is thankful to Central Electrochemical Research Institute (CSIR) for providing financial assistance and Department of Chemistry, Osmania University for providing facility, constant support and encouragement.


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • P. Balaswamy
    • 1
  • S. Aravind
    • 1
  • S. Purushotham Reddy
    • 1
  • B. Satyanarayana
    • 1
  1. 1.Department of ChemistryOsmania UniversityHyderabad, TelanganaIndia

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