Russian Journal of General Chemistry

, Volume 88, Issue 4, pp 682–688 | Cite as

A New Approach to the Synthesis of Functional Derivatives of 3-(4-Pyridinyl)-1H-indole and 4-(1H-Indol-3-yl)thieno[2,3-b]pyridine

  • V. V. Dotsenko
  • S. G. Krivokolysko
  • B. S. Krivokolysko
  • K. A. Frolov
Article
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Abstract

Sequential reaction of indole-3-carbaldehyde with cyanothioacetamide and KOH led to the formation of potassium 6-amino-4-(1H-indol-3-yl)-3,5-dicyanopyridine-2-thiolate. S-Alkylation of the latter afforded new functional derivatives of 3-(pyridine-4-yl)-1H-indole and 4-(1H-indol-3-yl)-thieno[2,3-b]pyridine.

Keywords

cyanothioacetamide 3-(pyridine-4-yl)-1H-indoles 6-amino-3,5-dicyanopyridine-2-thiolate Thorpe–Ziegler cyclization thieno[2,3-b]pyridines 

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Notes

Acknowledgments

This work was supported by the Ministry of Education and Science of the Russian Federation (project no. 4.5547.2017/BCh) using the equipment of the Ecological and Analytical Center of the Kuban State University (unique identifier RFMEFI59317X0008).

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • V. V. Dotsenko
    • 1
    • 2
  • S. G. Krivokolysko
    • 1
  • B. S. Krivokolysko
    • 1
  • K. A. Frolov
    • 1
  1. 1.Kuban State UniversityKrasnodarRussia
  2. 2.North-Caucasus Federal UniversityStavropolRussia

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