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Russian Journal of General Chemistry

, Volume 88, Issue 3, pp 587–595 | Cite as

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel 1,2,3-Triazole Tagged 5-[(1H-Indol-3-yl)methylene]pyrimidine-2,4,6(1H,3H,5H)trione Derivatives

  • Ashok Kumar
  • B. Sathish Kumar
  • E. Sreenivas
  • T. Subbaiah
Article
  • 34 Downloads

Abstract

Novel 5-{(1-[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]-1H-indol-3-yl)methylene}pyrimidine-2,4,6-(1H,3H,5H)trione derivatives (5a5k) were synthesized by the click reaction. All compounds 5a5k were characterized by 1H and 13C NMR, IR and Mass spectra and evaluated for their in vitro anticancer activity against cervical cancer cell lines. Among all, compound 5e (IC50 = 6.76 μM), shown high inhibitory activity. Docking analysis of all the compounds with the Lipid kinase PI3K-α revealed that the compound 5e fitted well in the active site pocket, showing the best docking score (LibDock) of 123.274.

Keywords

1,2,3-triazole indole click reaction cervical cancer molecular docking 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • Ashok Kumar
    • 1
    • 4
  • B. Sathish Kumar
    • 2
  • E. Sreenivas
    • 3
  • T. Subbaiah
    • 4
  1. 1.Department of ChemistrySreenidhi Institute of Science and TechnologyYamnampet, Ghatkesar, HyderabadIndia
  2. 2.Department of ChemistryOsmania UniversityHyderabadIndia
  3. 3.Bioinformatics DivisionAverin Biotech Pvt. Ltd. WindsorplazaNallakunta, HyderabadIndia
  4. 4.Department of ChemistryKoneru Lakshmaiah Deemed to be UniversityGreen Fields, Vaddeswaram, Guntur (Dist)India

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