Russian Journal of General Chemistry

, Volume 88, Issue 3, pp 573–579 | Cite as

Synthesis of Pd(II), Ag(I), Pt(IV), and Hg(II) Complexes with Nifuroxazide, Their Structure, DFT Modeling, and Antimicrobial and Anticancer Activity

  • M. Y. Nassar
  • W. H. El-Shwiniy
  • S. I. El-Desoky


New mononuclear complexes of Pd(II), Ag(I), Pt(IV), and Hg(II) with nifuroxazide were synthesized by the reaction of the metals salts with the drug. The complexes were characterized by elemental and thermal analysis and FT-IR, 1H NMR, and UV–Vis spectra. Stoichiometry of the complexes was determined to be 1: 2. Nifuroxazide (Nif.) drug is coordinated to the metal ions as a bidentate ligand via oxygen and nitrogen atoms of the C=O and hydrazone groups. Density functional theory (DFT) calculations were carried out at the B3LYP levels with LANL2DZ basis set for Ag(I) and Hg(II) ions, LANL2MB basis set for Pd(II) and Pt(IV) ions, and 6-31G(d,p) basis set for the other atoms. The complexes had high thermal stability. Tests for anticancer activity, breast cancer cell line (MCF7), demonstrated that Hg(II), Pt(IV), and Pd(II) metal complexes had higher activity than the free ligand.


nifuroxazide drug DFT calculation 1H NMR spectra thermal analysis anticancer 


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • M. Y. Nassar
    • 1
  • W. H. El-Shwiniy
    • 2
  • S. I. El-Desoky
    • 1
  1. 1.Chemistry Department, Faculty of ScienceBenha UniversityBenhaEgypt
  2. 2.Department of Chemistry, Faculty of ScienceZagazig UniversityZagazigEgypt

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